Noel J. Downes

Ledbury, ENG, United Kingdom

Last Updated: 09/26/2026

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Found 14 publications

Species selection for nonclinical safety assessment of drug candidates: Examples of current industry practice.

Species selection for nonclinical safety assessment of drug candidates: Examples of current industry practice.

Journal: Regulatory toxicology and pharmacology : RTP
Published: April 28, 2021

Opportunities for use of one species for longer-term toxicology testing during drug development: A cross-industry evaluation.

Opportunities for use of one species for longer-term toxicology testing during drug development: A cross-industry evaluation.

Journal: Regulatory toxicology and pharmacology : RTP
Published: October 09, 2019

An immunologically relevant rodent model demonstrates safety of therapy using a tumour-specific IgE.

An immunologically relevant rodent model demonstrates safety of therapy using a tumour-specific IgE.

Journal: Allergy
Published: April 02, 2018

An innovative investigative approach to characterize the effects observed in a combined fertility study in male and female rats.

An innovative investigative approach to characterize the effects observed in a combined fertility study in male and female rats.

Journal: Regulatory toxicology and pharmacology : RTP
Published: December 05, 2017

Reductive Metabolism Influences the Toxicity and Pharmacokinetics of the Hypoxia-Targeted Benzotriazine Di-Oxide Anticancer Agent SN30000 in Mice.

Reductive Metabolism Influences the Toxicity and Pharmacokinetics of the Hypoxia-Targeted Benzotriazine Di-Oxide Anticancer Agent SN30000 in Mice.

Journal: Frontiers in pharmacology
Published: June 26, 2017

Consideration of the Development of the Gastrointestinal Tract in the Choice of Species for Regulatory Juvenile Studies.

Consideration of the Development of the Gastrointestinal Tract in the Choice of Species for Regulatory Juvenile Studies.

Journal: Birth defects research
Published: May 31, 2017

Anti-Folate Receptor-α IgE but not IgG Recruits Macrophages to Attack Tumors via TNFα/MCP-1 Signaling.

Anti-Folate Receptor-α IgE but not IgG Recruits Macrophages to Attack Tumors via TNFα/MCP-1 Signaling.

Journal: Cancer research
Published: July 04, 2016

The incidence of congenital malformations and variations in Göttingen minipigs.

The incidence of congenital malformations and variations in Göttingen minipigs.

Journal: Reproductive toxicology (Elmsford, N.Y.)
Published: March 15, 2016

Vehicle Systems and Excipients Used in Minipig Drug Development Studies.

Vehicle Systems and Excipients Used in Minipig Drug Development Studies.

Journal: Toxicologic pathology
Published: December 18, 2015

Regulatory Forum Opinion Piece: Carcinogen Risk Assessment: The Move from Screens to Science.

Regulatory Forum Opinion Piece: Carcinogen Risk Assessment: The Move from Screens to Science.

Journal: Toxicologic pathology
Published: August 23, 2015

Organ data from the developing Göttingen minipig: first steps towards a juvenile PBPK model.

Organ data from the developing Göttingen minipig: first steps towards a juvenile PBPK model.

Journal: Journal of pharmacokinetics and pharmacodynamics
Published: August 18, 2015

Vigabatrin-induced CNS changes in juvenile rats: Induction, progression and recovery of myelin-related changes.

Vigabatrin-induced CNS changes in juvenile rats: Induction, progression and recovery of myelin-related changes.

Journal: Neurotoxicology
Published: July 13, 2014
Showing 1-12 of 14

Last Updated: 09/26/2026