Nooshin S. Safikhan

Vancouver, BC, Canada

Last Updated: 09/26/2026

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Found 8 publications

CD248 promotes insulin resistance by binding to the insulin receptor and dampening its insulin-induced autophosphorylation.

CD248 promotes insulin resistance by binding to the insulin receptor and dampening its insulin-induced autophosphorylation.

Journal: EBioMedicine
Published: July 15, 2023

CD248 enhances tissue factor procoagulant function, promoting arterial and venous thrombosis in mouse models.

CD248 enhances tissue factor procoagulant function, promoting arterial and venous thrombosis in mouse models.

Journal: Journal of thrombosis and haemostasis : JTH
Published: October 01, 2020

Sustained depletion of FXIII-A by inducing acquired FXIII-B deficiency.

Sustained depletion of FXIII-A by inducing acquired FXIII-B deficiency.

Journal: Blood
Published: January 21, 2020

Specific loss of adipocyte CD248 improves metabolic health via reduced white adipose tissue hypoxia, fibrosis and inflammation.

Specific loss of adipocyte CD248 improves metabolic health via reduced white adipose tissue hypoxia, fibrosis and inflammation.

Journal: EBioMedicine
Published: March 22, 2019

Dual role of interleukin-1β in islet amyloid formation and its β-cell toxicity: Implications for type 2 diabetes and islet transplantation.

Dual role of interleukin-1β in islet amyloid formation and its β-cell toxicity: Implications for type 2 diabetes and islet transplantation.

Journal: Diabetes, obesity & metabolism
Published: October 04, 2016

Amyloid formation reduces protein kinase B phosphorylation in primary islet β-cells which is improved by blocking IL-1β signaling.

Amyloid formation reduces protein kinase B phosphorylation in primary islet β-cells which is improved by blocking IL-1β signaling.

Journal: PloS one
Published: August 16, 2016

The role of caspase-8 in amyloid-induced beta cell death in human and mouse islets.

The role of caspase-8 in amyloid-induced beta cell death in human and mouse islets.

Journal: Diabetologia
Published: September 11, 2013

The glucagon-like peptide-1 receptor agonist exenatide restores impaired pro-islet amyloid polypeptide processing in cultured human islets: implications in type 2 diabetes and islet transplantation.

The glucagon-like peptide-1 receptor agonist exenatide restores impaired pro-islet amyloid polypeptide processing in cultured human islets: implications in type 2 diabetes and islet transplantation.

Journal: Diabetologia
Published: August 20, 2012
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Last Updated: 09/26/2026