Norbert Benda

Kurt Georg Kiesinger Allee 3
Bonn, NW 53175, Germany

Last Updated: 09/26/2026

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Found 34 publications

The Estimand Framework in Diagnostic Accuracy Studies.

The Estimand Framework in Diagnostic Accuracy Studies.

Journal: Statistics in medicine
Published: July 19, 2024

Methodological Insights on Biomarker-Based Patient Selection: A Review of Scientific Advice Procedures at the European Medicines Agency.

Methodological Insights on Biomarker-Based Patient Selection: A Review of Scientific Advice Procedures at the European Medicines Agency.

Journal: Clinical pharmacology and therapeutics
Published: July 12, 2024

Methods for non-proportional hazards in clinical trials: A systematic review.

Methods for non-proportional hazards in clinical trials: A systematic review.

Journal: Statistical methods in medical research
Published: April 09, 2024

Evidence generation throughout paediatric medicines life cycle: findings from collaborative work between European Medicines Agency (EMA) and EUnetHTA on use of extrapolation.

Evidence generation throughout paediatric medicines life cycle: findings from collaborative work between European Medicines Agency (EMA) and EUnetHTA on use of extrapolation.

Journal: British journal of pharmacology
Published: April 08, 2024

A Comparison of Statistical Methods for Time-To-Event Analyses in Randomized Controlled Trials Under Non-Proportional Hazards.

A Comparison of Statistical Methods for Time-To-Event Analyses in Randomized Controlled Trials Under Non-Proportional Hazards.

Journal: Statistics in medicine
Published: October 08, 2023

Sample size recalculation based on the prevalence in a randomized test-treatment study.

Sample size recalculation based on the prevalence in a randomized test-treatment study.

Journal: BMC medical research methodology
Published: February 25, 2022

Efficient Adaptive Designs for Clinical Trials of Interventions for COVID-19.

Efficient Adaptive Designs for Clinical Trials of Interventions for COVID-19.

Journal: Statistics in biopharmaceutical research
Published: June 30, 2021

Classification of Companion Diagnostics: A New Framework for Biomarker-Driven Patient Selection.

Classification of Companion Diagnostics: A New Framework for Biomarker-Driven Patient Selection.

Journal: Therapeutic innovation & regulatory science
Published: June 21, 2021

Effect size estimates from umbrella designs: Handling patients with a positive test result for multiple biomarkers using random or pragmatic subtrial allocation.

Effect size estimates from umbrella designs: Handling patients with a positive test result for multiple biomarkers using random or pragmatic subtrial allocation.

Journal: PloS one
Published: December 20, 2019

Blood-based systems biology biomarkers for next-generation clinical trials in Alzheimer's disease
.

Blood-based systems biology biomarkers for next-generation clinical trials in Alzheimer's disease
.

Journal: Dialogues in clinical neuroscience
Published: October 23, 2019

Blinded continuous information monitoring of recurrent event endpoints with time trends in clinical trials.

Blinded continuous information monitoring of recurrent event endpoints with time trends in clinical trials.

Journal: Statistics in medicine
Published: July 14, 2019

Change in Albuminuria and Estimated GFR as End Points for Clinical Trials in Early Stages of CKD: A Perspective From European Regulators.

Change in Albuminuria and Estimated GFR as End Points for Clinical Trials in Early Stages of CKD: A Perspective From European Regulators.

Journal: American journal of kidney diseases : the official journal of the National Kidney Foundation
Published: June 26, 2019
Showing 1-12 of 34

Last Updated: 09/26/2026