Norman L. Mack

Heidelberg, BW, Germany

Last Updated: 09/26/2026

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Found 19 publications

CAR T cells targeting the glycoprotein GD2 show potent antitumor efficacy in high-risk ependymoma models.

CAR T cells targeting the glycoprotein GD2 show potent antitumor efficacy in high-risk ependymoma models.

Journal: The Journal of clinical investigation

Published: November 25, 2025

The ITCC-P4 PDX Platform Enables Preclinical Testing of Pediatric Cancers.

The ITCC-P4 PDX Platform Enables Preclinical Testing of Pediatric Cancers.

Journal: Cancer research

Published: November 19, 2025

Preclinical drug screen identifies WEE1 inhibitor and vinca alkaloid as a combination treatment concept for Li-Fraumeni syndrome medulloblastoma.

Preclinical drug screen identifies WEE1 inhibitor and vinca alkaloid as a combination treatment concept for Li-Fraumeni syndrome medulloblastoma.

Journal: iScience

Published: May 07, 2025

Cellular hierarchies of embryonal tumors with multilayered rosettes are shaped by oncogenic microRNAs and receptor-ligand interactions.

Cellular hierarchies of embryonal tumors with multilayered rosettes are shaped by oncogenic microRNAs and receptor-ligand interactions.

Journal: Nature cancer

Published: August 24, 2024

Synergy of retinoic acid and BH3 mimetics in MYC(N)-driven embryonal nervous system tumours.

Synergy of retinoic acid and BH3 mimetics in MYC(N)-driven embryonal nervous system tumours.

Journal: British journal of cancer

Published: November 10, 2023

CD20-bispecific antibodies improve response to CD19-CAR T cells in lymphoma in vitro and CLL in vivo models.

CD20-bispecific antibodies improve response to CD19-CAR T cells in lymphoma in vitro and CLL in vivo models.

Journal: Blood

Published: September 27, 2023

Patient- and xenograft-derived organoids recapitulate pediatric brain tumor features and patient treatments.

Patient- and xenograft-derived organoids recapitulate pediatric brain tumor features and patient treatments.

Journal: EMBO molecular medicine

Published: June 21, 2023

Longitudinal omics data and preclinical treatment suggest the proteasome inhibitor carfilzomib as therapy for ibrutinib-resistant CLL.

Longitudinal omics data and preclinical treatment suggest the proteasome inhibitor carfilzomib as therapy for ibrutinib-resistant CLL.

Journal: Nature communications

Published: June 19, 2023

Sphingosine-1-Phosphate Recruits Macrophages and Microglia and Induces a Pro-Tumorigenic Phenotype That Favors Glioma Progression.

Sphingosine-1-Phosphate Recruits Macrophages and Microglia and Induces a Pro-Tumorigenic Phenotype That Favors Glioma Progression.

Journal: Cancers

Published: November 30, 2022

Predictive modeling of resistance to SMO inhibition in a patient-derived orthotopic xenograft model of SHH medulloblastoma.

Predictive modeling of resistance to SMO inhibition in a patient-derived orthotopic xenograft model of SHH medulloblastoma.

Journal: Neuro-oncology advances

Published: April 27, 2022

Carbon ion radiotherapy eradicates medulloblastomas with chromothripsis in an orthotopic Li-Fraumeni patient-derived mouse model.

Carbon ion radiotherapy eradicates medulloblastomas with chromothripsis in an orthotopic Li-Fraumeni patient-derived mouse model.

Journal: Neuro-oncology

Published: May 28, 2021

Interleukin-10 receptor signaling promotes the maintenance of a PD-1int TCF-1+ CD8+ T cell population that sustains anti-tumor immunity.

Interleukin-10 receptor signaling promotes the maintenance of a PD-1int TCF-1+ CD8+ T cell population that sustains anti-tumor immunity.

Journal: Immunity

Published: January 09, 2021

Showing 1-12 of 19

Last Updated: 09/26/2026