Last Updated: 09/26/2026
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Found 15 publications
A Rationally Designed Novel Bifunctional Human TNF-α- and Janus Kinase-Targeted soloMER Drug Conjugate (SDC) with a Neutrophil Elastase Cleavable Linker Delivering Inflammation Site-Specific Release of Payload.
Journal: Journal of medicinal chemistry
Published: April 07, 2026
Enhancing the Transdermal Delivery of 'Next Generation' Variable New Antigen Receptors Using Microarray Patch Technology: a Proof-of-Concept Study.
Journal: Journal of pharmaceutical sciences
Published: July 19, 2022
Overview, Generation, and Significance of Variable New Antigen Receptors (VNARs) as a Platform for Drug and Diagnostic Development.
Journal: Methods in molecular biology (Clifton, N.J.)
Published: February 14, 2022
In Vitro Maturation of a Humanized Shark VNAR Domain to Improve Its Biophysical Properties.
Journal: Methods in molecular biology (Clifton, N.J.)
Published: October 19, 2019
In Vitro ELISA and Cell-Based Assays Confirm the Low Immunogenicity of VNAR Therapeutic Constructs in a Mouse Model of Human RA: An Encouraging Milestone to Further Clinical Drug Development.
Journal: Journal of immunology research
Published: September 28, 2019
Uveitis Therapy With Shark Variable Novel Antigen Receptor Domains Targeting Tumor Necrosis Factor Alpha or Inducible T-Cell Costimulatory Ligand.
Journal: Translational vision science & technology
Published: December 04, 2018
An Anti-hTNF-α Variable New Antigen Receptor Format Demonstrates Superior in vivo Preclinical Efficacy to Humira® in a Transgenic Mouse Autoimmune Polyarthritis Disease Model.
Journal: Frontiers in immunology
Published: August 29, 2018
Next-generation flexible formats of VNAR domains expand the drug platform's utility and developability.
Journal: Biochemical Society transactions
Published: July 23, 2018
Novel, Anti-hTNF-α Variable New Antigen Receptor Formats with Enhanced Neutralizing Potency and Multifunctionality, Generated for Therapeutic Development.
Journal: Frontiers in immunology
Published: October 03, 2017
In Vitro Maturation of a Humanized Shark VNAR Domain to Improve Its Biophysical Properties to Facilitate Clinical Development.
Journal: Frontiers in immunology
Published: July 04, 2017
Last Updated: 09/26/2026