Oleksii S. Rukhlenko

Dublin, L, Ireland

Last Updated: 09/26/2026

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Found 33 publications

Polycomb Repressive Complex 2 drives flow-sensitive endothelial states underlying vascular inflammation and disease.

Polycomb Repressive Complex 2 drives flow-sensitive endothelial states underlying vascular inflammation and disease.

Journal: Proceedings of the National Academy of Sciences of the United States of America
Published: August 31, 2026

IFN γ and IFN γ mimetics prevent IFN-I-mediated TB susceptibility by regulating iron metabolism and lipid peroxidation.

IFN γ and IFN γ mimetics prevent IFN-I-mediated TB susceptibility by regulating iron metabolism and lipid peroxidation.

Journal: bioRxiv : the preprint server for biology
Published: July 17, 2026

A structure-based modeling approach identifies effective drug combinations for RAS-mutant acute myeloid leukemia.

A structure-based modeling approach identifies effective drug combinations for RAS-mutant acute myeloid leukemia.

Journal: iScience
Published: November 07, 2025

Lipid peroxidation and type I interferon coupling fuels pathogenic macrophage activation causing tuberculosis susceptibility.

Lipid peroxidation and type I interferon coupling fuels pathogenic macrophage activation causing tuberculosis susceptibility.

Journal: eLife
Published: October 02, 2025

Phase II Trial of Vemurafenib and Sorafenib Combination in Advanced KRAS-Mutated Metastatic Pancreatic Cancer.

Phase II Trial of Vemurafenib and Sorafenib Combination in Advanced KRAS-Mutated Metastatic Pancreatic Cancer.

Journal: Journal of immunotherapy and precision oncology
Published: August 11, 2025

Dual RAF inhibition outperforms RAF-MEK combinations for suppressing ERK signaling in KRAS mutant cells.

Dual RAF inhibition outperforms RAF-MEK combinations for suppressing ERK signaling in KRAS mutant cells.

Journal: NPJ systems biology and applications
Published: July 29, 2025

A structure-based modelling approach identifies effective drug combinations for RAS-mutant acute myeloid leukemia.

A structure-based modelling approach identifies effective drug combinations for RAS-mutant acute myeloid leukemia.

Journal: bioRxiv : the preprint server for biology
Published: July 14, 2025

cSTAR analysis identifies endothelial cell cycle as a key regulator of flow-dependent artery remodeling.

cSTAR analysis identifies endothelial cell cycle as a key regulator of flow-dependent artery remodeling.

Journal: Science advances
Published: January 03, 2025

Cell State Transition Models Stratify Breast Cancer Cell Phenotypes and Reveal New Therapeutic Targets.

Cell State Transition Models Stratify Breast Cancer Cell Phenotypes and Reveal New Therapeutic Targets.

Journal: Cancers
Published: May 07, 2024

Lipid Peroxidation and Type I Interferon Coupling Fuels Pathogenic Macrophage Activation Causing Tuberculosis Susceptibility.

Lipid Peroxidation and Type I Interferon Coupling Fuels Pathogenic Macrophage Activation Causing Tuberculosis Susceptibility.

Journal: bioRxiv : the preprint server for biology
Published: March 18, 2024

VEGF counteracts shear stress-determined arterial fate specification during capillary remodeling.

VEGF counteracts shear stress-determined arterial fate specification during capillary remodeling.

Journal: bioRxiv : the preprint server for biology
Published: February 08, 2024

Cell-specific models reveal conformation-specific RAF inhibitor combinations that synergistically inhibit ERK signaling in pancreatic cancer cells.

Cell-specific models reveal conformation-specific RAF inhibitor combinations that synergistically inhibit ERK signaling in pancreatic cancer cells.

Journal: Cell reports
Published: December 19, 2023
Showing 1-12 of 33

Last Updated: 09/26/2026