Olivier Duclos

Sanofi R&D
Chilly, 91380, France

Last Updated: 09/26/2026

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Found 12 publications

Optimization of Single Relaxin B-Chain Peptide Leads to the Identification of R2R01, a Potent, Long-Acting RXFP1 Agonist for Cardiovascular and Renal Diseases.

Optimization of Single Relaxin B-Chain Peptide Leads to the Identification of R2R01, a Potent, Long-Acting RXFP1 Agonist for Cardiovascular and Renal Diseases.

Journal: Journal of medicinal chemistry

Published: January 31, 2025

R2R01: A long-acting single-chain peptide agonist of RXFP1 for renal and cardiovascular diseases.

R2R01: A long-acting single-chain peptide agonist of RXFP1 for renal and cardiovascular diseases.

Journal: British journal of pharmacology

Published: November 09, 2023

Fatty acid acylated peptide therapeutics: discovery of omega-n oxidation of the lipid chain as a novel metabolic pathway in preclinical species.

Fatty acid acylated peptide therapeutics: discovery of omega-n oxidation of the lipid chain as a novel metabolic pathway in preclinical species.

Journal: Journal of pharmaceutical and biomedical analysis

Published: October 19, 2022

Characterization of a new potent and long-lasting single chain peptide agonist of RXFP1 in cells and in vivo translational models.

Characterization of a new potent and long-lasting single chain peptide agonist of RXFP1 in cells and in vivo translational models.

Journal: Scientific reports

Published: July 12, 2022

Impact of Cyclization and Methylation on Peptide Penetration through Droplet Interface Bilayers.

Impact of Cyclization and Methylation on Peptide Penetration through Droplet Interface Bilayers.

Journal: Langmuir : the ACS journal of surfaces and colloids

Published: April 22, 2022

Potent Lys Patch-Containing Stapled Peptides Targeting PCSK9.

Potent Lys Patch-Containing Stapled Peptides Targeting PCSK9.

Journal: Journal of medicinal chemistry

Published: July 16, 2021

Identification of Potent and Long-Acting Single-Chain Peptide Mimetics of Human Relaxin-2 for Cardiovascular Diseases.

Identification of Potent and Long-Acting Single-Chain Peptide Mimetics of Human Relaxin-2 for Cardiovascular Diseases.

Journal: Journal of medicinal chemistry

Published: February 08, 2021

Introduction of Non-natural Amino Acids Into T-Cell Epitopes to Mitigate Peptide-Specific T-Cell Responses.

Introduction of Non-natural Amino Acids Into T-Cell Epitopes to Mitigate Peptide-Specific T-Cell Responses.

Journal: Frontiers in immunology

Published: December 04, 2020

Membrane determinants for the passive translocation of analytes through droplet interface bilayers.

Membrane determinants for the passive translocation of analytes through droplet interface bilayers.

Journal: Soft matter

Published: June 17, 2020

Healthy Donors Exhibit a CD4 T Cell Repertoire Specific to the Immunogenic Human Hormone H2-Relaxin before Injection.

Healthy Donors Exhibit a CD4 T Cell Repertoire Specific to the Immunogenic Human Hormone H2-Relaxin before Injection.

Journal: Journal of immunology (Baltimore, Md. : 1950)

Published: June 18, 2018

Reversion of cardiac dysfunction by a novel orally available calcium/calmodulin-dependent protein kinase II inhibitor, RA306, in a genetic model of dilated cardiomyopathy.

Reversion of cardiac dysfunction by a novel orally available calcium/calmodulin-dependent protein kinase II inhibitor, RA306, in a genetic model of dilated cardiomyopathy.

Journal: Cardiovascular research

Published: June 15, 2018

CaMKII as a pathological mediator of ER stress, oxidative stress, and mitochondrial dysfunction in a murine model of nephronophthisis.

CaMKII as a pathological mediator of ER stress, oxidative stress, and mitochondrial dysfunction in a murine model of nephronophthisis.

Journal: American journal of physiology. Renal physiology

Published: September 21, 2015

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Last Updated: 09/26/2026