Olivier Mirguet

Croissy-sur-seine, 78290, France

Last Updated: 09/26/2026

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Found 15 publications

Targeting non-alcoholic fatty liver disease: Design, X-ray co-crystal structure and synthesis of 'first-in-kind' inhibitors of serine/threonine kinase25.

Targeting non-alcoholic fatty liver disease: Design, X-ray co-crystal structure and synthesis of 'first-in-kind' inhibitors of serine/threonine kinase25.

Journal: Bioorganic & medicinal chemistry letters

Published: June 29, 2022

Deep generative models for ligand-based de novo design applied to multi-parametric optimization.

Deep generative models for ligand-based de novo design applied to multi-parametric optimization.

Journal: Journal of computational chemistry

Published: September 29, 2021

Juniperanol: First total synthesis and evaluation in Type 2 Diabetes disease.

Juniperanol: First total synthesis and evaluation in Type 2 Diabetes disease.

Journal: Bioorganic chemistry

Published: August 08, 2019

Design and synthesis of bridged piperidine and piperazine isosteres.

Design and synthesis of bridged piperidine and piperazine isosteres.

Journal: Bioorganic & medicinal chemistry letters

Published: May 25, 2018

A new AMPK activator, GSK773, corrects fatty acid oxidation and differentiation defect in CPT2-deficient myotubes.

A new AMPK activator, GSK773, corrects fatty acid oxidation and differentiation defect in CPT2-deficient myotubes.

Journal: Human molecular genetics

Published: May 24, 2018

Development of a Series of Kynurenine 3-Monooxygenase Inhibitors Leading to a Clinical Candidate for the Treatment of Acute Pancreatitis.

Development of a Series of Kynurenine 3-Monooxygenase Inhibitors Leading to a Clinical Candidate for the Treatment of Acute Pancreatitis.

Journal: Journal of medicinal chemistry

Published: April 12, 2017

The discovery of potent and selective kynurenine 3-monooxygenase inhibitors for the treatment of acute pancreatitis.

The discovery of potent and selective kynurenine 3-monooxygenase inhibitors for the treatment of acute pancreatitis.

Journal: Bioorganic & medicinal chemistry letters

Published: January 09, 2017

Kynurenine-3-monooxygenase inhibition prevents multiple organ failure in rodent models of acute pancreatitis.

Kynurenine-3-monooxygenase inhibition prevents multiple organ failure in rodent models of acute pancreatitis.

Journal: Nature medicine

Published: September 12, 2015

The discovery of I-BET726 (GSK1324726A), a potent tetrahydroquinoline ApoA1 up-regulator and selective BET bromodomain inhibitor.

The discovery of I-BET726 (GSK1324726A), a potent tetrahydroquinoline ApoA1 up-regulator and selective BET bromodomain inhibitor.

Journal: Journal of medicinal chemistry

Published: September 25, 2014

Discovery of epigenetic regulator I-BET762: lead optimization to afford a clinical candidate inhibitor of the BET bromodomains.

Discovery of epigenetic regulator I-BET762: lead optimization to afford a clinical candidate inhibitor of the BET bromodomains.

Journal: Journal of medicinal chemistry

Published: September 11, 2013

Naphthyridines as novel BET family bromodomain inhibitors.

Naphthyridines as novel BET family bromodomain inhibitors.

Journal: ChemMedChem

Published: June 10, 2013

Discovery of Pyridones As Oral AMPK Direct Activators.

Discovery of Pyridones As Oral AMPK Direct Activators.

Journal: ACS medicinal chemistry letters

Published: April 24, 2013

Showing 1-12 of 15

Last Updated: 09/26/2026