Orthis Saha

Lille, France

Last Updated: 09/26/2026

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Found 10 publications

Non-microglial downregulation of PLCG2 impairs synaptic function and elicits Alzheimer disease-related hallmarks.

Non-microglial downregulation of PLCG2 impairs synaptic function and elicits Alzheimer disease-related hallmarks.

Journal: bioRxiv : the preprint server for biology
Published: April 03, 2026

PLCG2 downregulation impairs synaptic function and increases Alzheimer's disease hallmarks in neuronal cultures.

PLCG2 downregulation impairs synaptic function and increases Alzheimer's disease hallmarks in neuronal cultures.

Journal: Nature genetics
Published: May 17, 2024

Amyloid-Beta Peptides Trigger Premature Functional and Gene Expression Alterations in Human-Induced Neurons.

Amyloid-Beta Peptides Trigger Premature Functional and Gene Expression Alterations in Human-Induced Neurons.

Journal: Biomedicines
Published: August 30, 2023

The Alzheimer's disease risk gene BIN1 regulates activity-dependent gene expression in human-induced glutamatergic neurons.

The Alzheimer's disease risk gene BIN1 regulates activity-dependent gene expression in human-induced glutamatergic neurons.

Journal: Molecular psychiatry
Published: June 03, 2023

The Alzheimer susceptibility gene BIN1 induces isoform-dependent neurotoxicity through early endosome defects.

The Alzheimer susceptibility gene BIN1 induces isoform-dependent neurotoxicity through early endosome defects.

Journal: Acta neuropathologica communications
Published: October 20, 2021

The "sacral parasympathetic": ontogeny and anatomy of a myth.

The "sacral parasympathetic": ontogeny and anatomy of a myth.

Journal: Clinical autonomic research : official journal of the Clinical Autonomic Research Society
Published: September 01, 2017

Proteomic analysis reveals novel ligands and substrates for LNX1 E3 ubiquitin ligase.

Proteomic analysis reveals novel ligands and substrates for LNX1 E3 ubiquitin ligase.

Journal: PloS one
Published: July 04, 2017

Decreased Anxiety-Related Behaviour but Apparently Unperturbed NUMB Function in Ligand of NUMB Protein-X (LNX) 1/2 Double Knockout Mice.

Decreased Anxiety-Related Behaviour but Apparently Unperturbed NUMB Function in Ligand of NUMB Protein-X (LNX) 1/2 Double Knockout Mice.

Journal: Molecular neurobiology
Published: August 23, 2016

The sacral autonomic outflow is sympathetic.

The sacral autonomic outflow is sympathetic.

Journal: Science (New York, N.Y.)
Published: July 12, 2016

Tight, cell type-specific control of LNX expression in the nervous system, at the level of transcription, translation and protein stability.

Tight, cell type-specific control of LNX expression in the nervous system, at the level of transcription, translation and protein stability.

Journal: Gene
Published: April 19, 2014
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Last Updated: 09/26/2026