Otavio A. Chaves

BR 465, Km 47
Seropedica, RJ 23890000, Brazil

Last Updated: 09/26/2026

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Found 63 publications

Structure-enabled enhancement of potency in a metronidazole-benznidazole hybrid: design, synthesis, and evaluation of antitrypanosomal activity of a benzylamide-linked 5-nitroimidazole.

Structure-enabled enhancement of potency in a metronidazole-benznidazole hybrid: design, synthesis, and evaluation of antitrypanosomal activity of a benzylamide-linked 5-nitroimidazole.

Journal: Frontiers in pharmacology

Published: February 16, 2026

Synthesis and functional characterization of a recombinant HIV-1 reverse transcriptase variant carrying twelve drug-resistance mutations as a platform for antiretroviral screening.

Synthesis and functional characterization of a recombinant HIV-1 reverse transcriptase variant carrying twelve drug-resistance mutations as a platform for antiretroviral screening.

Journal: International journal of biological macromolecules

Published: November 20, 2025

High antioxidant and antibiofilm activity of manganese (II and III) complexes derived from pyridoxal and aromatic hydrazides.

High antioxidant and antibiofilm activity of manganese (II and III) complexes derived from pyridoxal and aromatic hydrazides.

Journal: Journal of inorganic biochemistry

Published: September 09, 2025

Studies on the toxic effects of three regioisomeric methoxylated xanthones against Trypanosoma cruzi amastigotes and their binding with human serum albumin.

Studies on the toxic effects of three regioisomeric methoxylated xanthones against Trypanosoma cruzi amastigotes and their binding with human serum albumin.

Journal: International journal of biological macromolecules

Published: June 19, 2025

Antitumoral Profile of 1,3,4-Thiadiazolium Salts: Insights Into a Combinatory Therapeutic Approach With Flavonoid Quercetin.

Antitumoral Profile of 1,3,4-Thiadiazolium Salts: Insights Into a Combinatory Therapeutic Approach With Flavonoid Quercetin.

Journal: Chemistry & biodiversity

Published: June 05, 2025

Synthesis of Novel Tetra-Substituted Pyrazole Derivatives Using Microwave Irradiation and Their Anti-Leukemic Activity Against Jurkat Cells.

Synthesis of Novel Tetra-Substituted Pyrazole Derivatives Using Microwave Irradiation and Their Anti-Leukemic Activity Against Jurkat Cells.

Journal: Molecules (Basel, Switzerland)

Published: May 29, 2025

Design and Synthesis of Bis-Chalcones as Curcumin Simplified Analogs and Assessment of Their Antiproliferative Activities Against Human Lung Cancer Cells and Trypanosoma cruzi Amastigotes.

Design and Synthesis of Bis-Chalcones as Curcumin Simplified Analogs and Assessment of Their Antiproliferative Activities Against Human Lung Cancer Cells and Trypanosoma cruzi Amastigotes.

Journal: Pharmaceuticals (Basel, Switzerland)

Published: February 19, 2025

The presence of NSAIDs may affect the binding capacity of serum albumin to the natural products hymecromone and umbelliferone.

The presence of NSAIDs may affect the binding capacity of serum albumin to the natural products hymecromone and umbelliferone.

Journal: International journal of biological macromolecules

Published: September 13, 2024

Lapachol, a natural food component, interacts with human serum albumin: Insights of its impact on the pharmacokinetics of clinically used drugs.

Lapachol, a natural food component, interacts with human serum albumin: Insights of its impact on the pharmacokinetics of clinically used drugs.

Journal: International journal of biological macromolecules

Published: September 03, 2024

Light exposure of tetra-cationic porphyrins containing peripheral Pd(II)-bipyridyl complexes and the induced effects on purified DNA molecule, fibroblast and melanoma cell lines.

Light exposure of tetra-cationic porphyrins containing peripheral Pd(II)-bipyridyl complexes and the induced effects on purified DNA molecule, fibroblast and melanoma cell lines.

Journal: Photochemistry and photobiology

Published: May 29, 2024

Revisiting and Updating the Interaction between Human Serum Albumin and the Non-Steroidal Anti-Inflammatory Drugs Ketoprofen and Ketorolac.

Revisiting and Updating the Interaction between Human Serum Albumin and the Non-Steroidal Anti-Inflammatory Drugs Ketoprofen and Ketorolac.

Journal: Molecules (Basel, Switzerland)

Published: May 11, 2024

Folding Kinetics and Volume Variation of the β-Hairpin Peptide Chignolin upon Ultrafast pH-Jumps.

Folding Kinetics and Volume Variation of the β-Hairpin Peptide Chignolin upon Ultrafast pH-Jumps.

Journal: The journal of physical chemistry. B

Published: May 11, 2024

Showing 1-12 of 63

Last Updated: 09/26/2026