Pamela J. Shaw-Dame

Glossop Road
Sheffield, ENG S102JF, United Kingdom

Last Updated: 09/26/2026

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Found 17 publications

Hypothesis-free evaluation of circulating metabolome provides cell-specific insights regarding the role of energy substrate availability in amyotrophic lateral sclerosis.

Hypothesis-free evaluation of circulating metabolome provides cell-specific insights regarding the role of energy substrate availability in amyotrophic lateral sclerosis.

Journal: BMC medicine

Published: October 08, 2025

M102 activates both NRF2 and HSF1 transcription factor pathways and is neuroprotective in cell and animal models of amyotrophic lateral sclerosis.

M102 activates both NRF2 and HSF1 transcription factor pathways and is neuroprotective in cell and animal models of amyotrophic lateral sclerosis.

Journal: Molecular neurodegeneration

Published: June 24, 2025

The four most common genetic subtypes of amyotrophic lateral sclerosis: state of the art and future directions.

The four most common genetic subtypes of amyotrophic lateral sclerosis: state of the art and future directions.

Journal: The Lancet. Neurology

Published: March 28, 2025

Current neuroprotective therapies and future prospects for motor neuron disease.

Current neuroprotective therapies and future prospects for motor neuron disease.

Journal: International review of neurobiology

Published: May 27, 2024

Amyotrophic lateral sclerosis: a neurodegenerative disorder poised for successful therapeutic translation.

Amyotrophic lateral sclerosis: a neurodegenerative disorder poised for successful therapeutic translation.

Journal: Nature reviews. Drug discovery

Published: November 11, 2022

Prospects for gene replacement therapies in amyotrophic lateral sclerosis.

Prospects for gene replacement therapies in amyotrophic lateral sclerosis.

Journal: Nature reviews. Neurology

Published: November 10, 2022

Physical exercise is a risk factor for amyotrophic lateral sclerosis: Convergent evidence from Mendelian randomisation, transcriptomics and risk genotypes.

Physical exercise is a risk factor for amyotrophic lateral sclerosis: Convergent evidence from Mendelian randomisation, transcriptomics and risk genotypes.

Journal: EBioMedicine

Published: March 19, 2021

Value of systematic genetic screening of patients with amyotrophic lateral sclerosis.

Value of systematic genetic screening of patients with amyotrophic lateral sclerosis.

Journal: Journal of neurology, neurosurgery, and psychiatry

Published: September 01, 2020

Rare Variant Burden Analysis within Enhancers Identifies CAV1 as an ALS Risk Gene.

Rare Variant Burden Analysis within Enhancers Identifies CAV1 as an ALS Risk Gene.

Journal: Cell reports

Published: May 13, 2020

Mutations in the Glycosyltransferase Domain of GLT8D1 Are Associated with Familial Amyotrophic Lateral Sclerosis.

Mutations in the Glycosyltransferase Domain of GLT8D1 Are Associated with Familial Amyotrophic Lateral Sclerosis.

Journal: Cell reports

Published: August 24, 2018

Translating SOD1 Gene Silencing toward the Clinic: A Highly Efficacious, Off-Target-free, and Biomarker-Supported Strategy for fALS.

Translating SOD1 Gene Silencing toward the Clinic: A Highly Efficacious, Off-Target-free, and Biomarker-Supported Strategy for fALS.

Journal: Molecular therapy. Nucleic acids

Published: February 08, 2018

Viral delivery of C9orf72 hexanucleotide repeat expansions in mice leads to repeat-length-dependent neuropathology and behavioural deficits.

Viral delivery of C9orf72 hexanucleotide repeat expansions in mice leads to repeat-length-dependent neuropathology and behavioural deficits.

Journal: Disease models & mechanisms

Published: March 07, 2017

Showing 1-12 of 17

Last Updated: 09/26/2026