Pamela M. Kleikers

Maastricht, LI, Netherlands

Last Updated: 09/26/2026

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Found 16 publications

Nutritional L-Citrulline and Tetrahydrobiopterin in Peripheral Artery Disease: A Phase II Randomized Trial (CIPER Study).

Nutritional L-Citrulline and Tetrahydrobiopterin in Peripheral Artery Disease: A Phase II Randomized Trial (CIPER Study).

Journal: JACC. Advances

Published: July 18, 2024

Endothelial reactive oxygen-forming NADPH oxidase 5 is a possible player in diabetic aortic aneurysm but not atherosclerosis.

Endothelial reactive oxygen-forming NADPH oxidase 5 is a possible player in diabetic aortic aneurysm but not atherosclerosis.

Journal: Scientific reports

Published: March 16, 2022

Un-biased housekeeping gene panel selection for high-validity gene expression analysis.

Un-biased housekeeping gene panel selection for high-validity gene expression analysis.

Journal: Scientific reports

Published: December 09, 2021

NOX5-induced uncoupling of endothelial NO synthase is a causal mechanism and theragnostic target of an age-related hypertension endotype.

NOX5-induced uncoupling of endothelial NO synthase is a causal mechanism and theragnostic target of an age-related hypertension endotype.

Journal: PLoS biology

Published: February 01, 2020

From single drug targets to synergistic network pharmacology in ischemic stroke.

From single drug targets to synergistic network pharmacology in ischemic stroke.

Journal: Proceedings of the National Academy of Sciences of the United States of America

Published: March 22, 2019

NOX4-dependent neuronal autotoxicity and BBB breakdown explain the superior sensitivity of the brain to ischemic damage.

NOX4-dependent neuronal autotoxicity and BBB breakdown explain the superior sensitivity of the brain to ischemic damage.

Journal: Proceedings of the National Academy of Sciences of the United States of America

Published: November 01, 2017

A diseasome cluster-based drug repurposing of soluble guanylate cyclase activators from smooth muscle relaxation to direct neuroprotection.

A diseasome cluster-based drug repurposing of soluble guanylate cyclase activators from smooth muscle relaxation to direct neuroprotection.

Journal: NPJ systems biology and applications

Published: August 10, 2017

NOS knockout or inhibition but not disrupting PSD-95-NOS interaction protect against ischemic brain damage.

NOS knockout or inhibition but not disrupting PSD-95-NOS interaction protect against ischemic brain damage.

Journal: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism

Published: February 22, 2016

SFRR-E Young Investigator AwardeeNOXing out stroke: Identification of NOX4 and 5as targets in blood-brain-barrier stabilisation and neuroprotection.

SFRR-E Young Investigator AwardeeNOXing out stroke: Identification of NOX4 and 5as targets in blood-brain-barrier stabilisation and neuroprotection.

Journal: Free radical biology & medicine

Published: October 14, 2015

A combined pre-clinical meta-analysis and randomized confirmatory trial approach to improve data validity for therapeutic target validation.

A combined pre-clinical meta-analysis and randomized confirmatory trial approach to improve data validity for therapeutic target validation.

Journal: Scientific reports

Published: February 18, 2015

Evolution of NADPH Oxidase Inhibitors: Selectivity and Mechanisms for Target Engagement.

Evolution of NADPH Oxidase Inhibitors: Selectivity and Mechanisms for Target Engagement.

Journal: Antioxidants & redox signaling

Published: January 04, 2014

Neuroprotection after stroke by targeting NOX4 as a source of oxidative stress.

Neuroprotection after stroke by targeting NOX4 as a source of oxidative stress.

Journal: Antioxidants & redox signaling

Published: September 04, 2012

Showing 1-12 of 16

Last Updated: 09/26/2026