Paola Grandi

Functional Genomics R&D
Heidelberg, BW 69117, Germany

Last Updated: 09/26/2026

Save publications for later

Sign Up

Not sure about your diagnosis?

Check Your Symptoms

Found 59 publications

BET Isoform Selectivity through Diverse Linkers for Bivalent Inhibitors: GSK785, a BRD2/4-Selective Bivalent BET Inhibitor.

BET Isoform Selectivity through Diverse Linkers for Bivalent Inhibitors: GSK785, a BRD2/4-Selective Bivalent BET Inhibitor.

Journal: Journal of medicinal chemistry

Published: December 30, 2025

Society for Immunotherapy of Cancer (SITC) consensus statement on essential biomarkers for immunotherapy clinical protocols.

Society for Immunotherapy of Cancer (SITC) consensus statement on essential biomarkers for immunotherapy clinical protocols.

Journal: Journal for immunotherapy of cancer

Published: February 05, 2025

Synergistic Effects of PARP Inhibition and Cholesterol Biosynthesis Pathway Modulation.

Synergistic Effects of PARP Inhibition and Cholesterol Biosynthesis Pathway Modulation.

Journal: Cancer research communications

Published: January 17, 2024

Network integration of thermal proteome profiling with multi-omics data decodes PARP inhibition.

Network integration of thermal proteome profiling with multi-omics data decodes PARP inhibition.

Journal: Molecular systems biology

Published: January 17, 2024

Integrated metabolic-transcriptomic network identifies immunometabolic modulations in human macrophages.

Integrated metabolic-transcriptomic network identifies immunometabolic modulations in human macrophages.

Journal: Cell reports

Published: November 23, 2023

Single-cell multi-omic and spatial profiling of human kidneys implicates the fibrotic microenvironment in kidney disease progression.

Single-cell multi-omic and spatial profiling of human kidneys implicates the fibrotic microenvironment in kidney disease progression.

Journal: Nature genetics

Published: July 27, 2023

mRNA export factors store nascent transcripts within nuclear speckles as an adaptive response to transient global inhibition of transcription.

mRNA export factors store nascent transcripts within nuclear speckles as an adaptive response to transient global inhibition of transcription.

Journal: Molecular cell

Published: June 06, 2023

Discovery of a first-in-class reversible DNMT1-selective inhibitor with improved tolerability and efficacy in acute myeloid leukemia.

Discovery of a first-in-class reversible DNMT1-selective inhibitor with improved tolerability and efficacy in acute myeloid leukemia.

Journal: Nature cancer

Published: November 18, 2021

Optimization of a Series of 2,3-Dihydrobenzofurans as Highly Potent, Second Bromodomain (BD2)-Selective, Bromo and Extra-Terminal Domain (BET) Inhibitors.

Optimization of a Series of 2,3-Dihydrobenzofurans as Highly Potent, Second Bromodomain (BD2)-Selective, Bromo and Extra-Terminal Domain (BET) Inhibitors.

Journal: Journal of medicinal chemistry

Published: July 14, 2021

Fragment-based Scaffold Hopping: Identification of Potent, Selective, and Highly Soluble Bromo and Extra Terminal Domain (BET) Second Bromodomain (BD2) Inhibitors.

Fragment-based Scaffold Hopping: Identification of Potent, Selective, and Highly Soluble Bromo and Extra Terminal Domain (BET) Second Bromodomain (BD2) Inhibitors.

Journal: Journal of medicinal chemistry

Published: July 13, 2021

Discovery of a Highly Selective BET BD2 Inhibitor from a DNA-Encoded Library Technology Screening Hit.

Discovery of a Highly Selective BET BD2 Inhibitor from a DNA-Encoded Library Technology Screening Hit.

Journal: Journal of medicinal chemistry

Published: July 12, 2021

Identification of a Series of N-Methylpyridine-2-carboxamides as Potent and Selective Inhibitors of the Second Bromodomain (BD2) of the Bromo and Extra Terminal Domain (BET) Proteins.

Identification of a Series of N-Methylpyridine-2-carboxamides as Potent and Selective Inhibitors of the Second Bromodomain (BD2) of the Bromo and Extra Terminal Domain (BET) Proteins.

Journal: Journal of medicinal chemistry

Published: July 07, 2021

Showing 1-12 of 59

Last Updated: 09/26/2026