Last Updated: 09/26/2026
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Found 30 publications
Depression severity and efficacy outcomes: post hoc analyses from a phase 3 trial of esmethadone for the adjunctive treatment of major depressive disorder with inadequate response to standard antidepressants.
Journal: International clinical psychopharmacology
Published: February 27, 2026
Design, Synthesis, and Pharmacokinetic Profiling of Fluorinated Reversible N-Alkyl Carbamate Derivatives of Psilocin for Sub-Hallucinogenic Brain Exposure.
Journal: Journal of medicinal chemistry
Published: January 26, 2026
Low, non-psychedelic doses of psilocybin as a novel treatment for MASLD, obesity and type 2 diabetes via 5-HT2B receptor-dependent mechanisms.
Journal: Pharmacological research
Published: October 30, 2025
Esmethadone (REL-1017) in Patients With Major Depressive Disorder and Antidepressant Tachyphylaxis: An Exploratory Post Hoc Analysis From a Phase 3 Randomized Controlled Trial.
Journal: The Journal of clinical psychiatry
Published: October 08, 2025
Reasons for Maintaining the Classification of Esmethadone as an Investigational Uncompetitive NMDAR Antagonist Rapid Antidepressant: Reply to Ferré and Michaelides.
Journal: The Journal of clinical psychiatry
Published: September 18, 2025
Emerging mechanisms of psilocybin-induced neuroplasticity.
Journal: Trends in pharmacological sciences
Published: July 08, 2025
New Synthesis and Pharmacological Evaluation of Enantiomerically Pure (R)- and (S)-Methadone Metabolites as N-Methyl-d-aspartate Receptor Antagonists.
Journal: Journal of medicinal chemistry
Published: February 25, 2025
Long-Term Safety and Efficacy of Esmethadone in Patients With Major Depressive Disorder: Findings From a 12-Month Open-Label Study.
Journal: The Journal of clinical psychiatry
Published: February 25, 2025
A novel artificial intelligence-based methodology to predict non-specific response to treatment.
Journal: Psychiatry research
Published: December 09, 2024
N-methyl-D-aspartate Receptors and Depression: Linking Psychopharmacology, Pathology and Physiology in a Unifying Hypothesis for the Epigenetic Code of Neural Plasticity.
Journal: Pharmaceuticals (Basel, Switzerland)
Published: October 07, 2024
Efficacy and Safety of Esmethadone (REL-1017) in Patients With Major Depressive Disorder and Inadequate Response to Standard Antidepressants: A Phase 3 Randomized Controlled Trial.
Journal: The Journal of clinical psychiatry
Published: June 25, 2024
Last Updated: 09/26/2026