Paolo Malune

Cagliari, 09124, Italy

Last Updated: 09/26/2026

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Found 11 publications

γ-Monoalkyl triphosphate analogues of acyclic nucleoside phosphonates inhibit SARS-CoV-2 replication in vitro by inducing dissociation of the minimal replication-transcription complex.

γ-Monoalkyl triphosphate analogues of acyclic nucleoside phosphonates inhibit SARS-CoV-2 replication in vitro by inducing dissociation of the minimal replication-transcription complex.

Journal: Antiviral research

Published: March 18, 2026

Identification of Nsp15 inhibitors restoring interferon-dependent antiviral activity against SARS-CoV-2.

Identification of Nsp15 inhibitors restoring interferon-dependent antiviral activity against SARS-CoV-2.

Journal: Antiviral research

Published: January 28, 2026

Dual-Site Inhibition of SARS-CoV-2 RNA-Dependent RNA Polymerase by Small Molecules Able to Block Viral Replication Identified through a Computer-Aided Drug Discovery Approach.

Dual-Site Inhibition of SARS-CoV-2 RNA-Dependent RNA Polymerase by Small Molecules Able to Block Viral Replication Identified through a Computer-Aided Drug Discovery Approach.

Journal: ACS infectious diseases

Published: September 26, 2025

Unveiling SARS-CoV-2's heart: role, structure and inhibition of SARS-CoV-2 RNA-dependent RNA polymerase.

Unveiling SARS-CoV-2's heart: role, structure and inhibition of SARS-CoV-2 RNA-dependent RNA polymerase.

Journal: Antiviral research

Published: March 27, 2025

The efficiency of high-throughput screening (HTS) and in-silico data analysis during medical emergencies: Identification of effective antiviral 3CLpro inhibitors.

The efficiency of high-throughput screening (HTS) and in-silico data analysis during medical emergencies: Identification of effective antiviral 3CLpro inhibitors.

Journal: Antiviral research

Published: November 18, 2024

Cys44 of SARS-CoV-2 3CLpro affects its catalytic activity.

Cys44 of SARS-CoV-2 3CLpro affects its catalytic activity.

Journal: International journal of biological macromolecules

Published: September 05, 2024

New Thiazolidine-4-One Derivatives as SARS-CoV-2 Main Protease Inhibitors.

New Thiazolidine-4-One Derivatives as SARS-CoV-2 Main Protease Inhibitors.

Journal: Pharmaceuticals (Basel, Switzerland)

Published: April 15, 2024

Drug repurposing screen to identify inhibitors of the RNA polymerase (nsp12) and helicase (nsp13) from SARS-CoV-2 replication and transcription complex.

Drug repurposing screen to identify inhibitors of the RNA polymerase (nsp12) and helicase (nsp13) from SARS-CoV-2 replication and transcription complex.

Journal: Virus research

Published: August 28, 2023

Strigolactones as Broad-Spectrum Antivirals against β-Coronaviruses through Targeting the Main Protease Mpro.

Strigolactones as Broad-Spectrum Antivirals against β-Coronaviruses through Targeting the Main Protease Mpro.

Journal: ACS infectious diseases

Published: June 26, 2023

Targeting SARS-CoV-2 Main Protease: A Successful Story Guided by an In Silico Drug Repurposing Approach.

Targeting SARS-CoV-2 Main Protease: A Successful Story Guided by an In Silico Drug Repurposing Approach.

Journal: Journal of chemical information and modeling

Published: May 25, 2023

Molecular Characterization of Severe Acute Respiratory Syndrome Coronavirus 2 Isolates From Central Inner Sardinia.

Molecular Characterization of Severe Acute Respiratory Syndrome Coronavirus 2 Isolates From Central Inner Sardinia.

Journal: Frontiers in microbiology

Published: December 02, 2021

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Last Updated: 09/26/2026