Pascale Dehertogh
Beerse, VLG, Belgium
Last Updated: 09/26/2026
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Found 12 publications
Antiviral Properties and Mechanism of Action Studies of the Hepatitis B Virus Capsid Assembly Modulator JNJ-56136379.
Journal: Antimicrobial agents and chemotherapy
Published: December 10, 2019
Anti-HBV activity of the HBV capsid assembly modulator JNJ-56136379 across full-length genotype A-H clinical isolates and core site-directed mutants in vitro.
Journal: The Journal of antimicrobial chemotherapy
Published: November 27, 2019
Synthesis and Evaluation of N-Phenyl-3-sulfamoyl-benzamide Derivatives as Capsid Assembly Modulators Inhibiting Hepatitis B Virus (HBV).
Journal: Journal of medicinal chemistry
Published: June 16, 2018
Antiviral profiling of the capsid assembly modulator BAY41-4109 on full-length HBV genotype A-H clinical isolates and core site-directed mutants in vitro.
Journal: Antiviral research
Published: March 28, 2017
Capsid Assembly Modulators Have a Dual Mechanism of Action in Primary Human Hepatocytes Infected with Hepatitis B Virus.
Journal: Antimicrobial agents and chemotherapy
Published: March 16, 2017
Discovery and early development of TMC647055, a non-nucleoside inhibitor of the hepatitis C virus NS5B polymerase.
Journal: Journal of medicinal chemistry
Published: October 23, 2013
Identification of HIV-1 reverse transcriptase inhibitors using a scintillation proximity assay.
Journal: Methods in molecular biology (Clifton, N.J.)
Published: July 04, 2013
TMC647055, a potent nonnucleoside hepatitis C virus NS5B polymerase inhibitor with cross-genotypic coverage.
Journal: Antimicrobial agents and chemotherapy
Published: June 20, 2012
Finger loop inhibitors of the HCV NS5b polymerase. Part II. Optimization of tetracyclic indole-based macrocycle leading to the discovery of TMC647055.
Journal: Bioorganic & medicinal chemistry letters
Published: February 28, 2012
Finger-loop inhibitors of the HCV NS5b polymerase. Part 1: Discovery and optimization of novel 1,6- and 2,6-macrocyclic indole series.
Journal: Bioorganic & medicinal chemistry letters
Published: February 24, 2012
Structure-based macrocyclization yields hepatitis C virus NS5B inhibitors with improved binding affinities and pharmacokinetic properties.
Journal: Angewandte Chemie (International ed. in English)
Published: January 05, 2012
Showing 1-12 of 12
Last Updated: 09/26/2026