Patrick Downey

Braine L'alleud, 1420, Belgium

Last Updated: 09/26/2026

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Found 17 publications

A high-fidelity microfluidic platform reveals retrograde propagation as the main mechanism of α-Synuclein spread in human neurons.

A high-fidelity microfluidic platform reveals retrograde propagation as the main mechanism of α-Synuclein spread in human neurons.

Journal: NPJ Parkinson's disease

Published: November 21, 2024

Differential role of C-terminal truncations on alpha-synuclein pathology and Lewy body formation.

Differential role of C-terminal truncations on alpha-synuclein pathology and Lewy body formation.

Journal: NPJ Parkinson's disease

Published: November 10, 2024

Two-color coincidence single-molecule pulldown for the specific detection of disease-associated protein aggregates.

Two-color coincidence single-molecule pulldown for the specific detection of disease-associated protein aggregates.

Journal: Science advances

Published: November 15, 2023

Single-Molecule Two-Color Coincidence Detection of Unlabeled alpha-Synuclein Aggregates.

Single-Molecule Two-Color Coincidence Detection of Unlabeled alpha-Synuclein Aggregates.

Journal: Angewandte Chemie (International ed. in English)

Published: November 14, 2022

Single-Molecule Two-Color Coincidence Detection of Unlabeled alpha-Synuclein Aggregates.

Single-Molecule Two-Color Coincidence Detection of Unlabeled alpha-Synuclein Aggregates.

Journal: Angewandte Chemie (Weinheim an der Bergstrasse, Germany)

Published: November 14, 2022

Artificial intelligence-based clustering and characterization of Parkinson's disease trajectories.

Artificial intelligence-based clustering and characterization of Parkinson's disease trajectories.

Journal: Scientific reports

Published: August 02, 2022

A modular microfluidic platform to enable complex and customisable in vitro models for neuroscience.

A modular microfluidic platform to enable complex and customisable in vitro models for neuroscience.

Journal: Lab on a chip

Published: April 25, 2022

A rapid α-synuclein seed assay of Parkinson's disease CSF panel shows high diagnostic accuracy.

A rapid α-synuclein seed assay of Parkinson's disease CSF panel shows high diagnostic accuracy.

Journal: Annals of clinical and translational neurology

Published: October 06, 2020

Monitoring of a progressive functional dopaminergic deficit in the A53T-AAV synuclein rats by combining 6-[18F]fluoro-L-m-tyrosine imaging and motor performances analysis.

Monitoring of a progressive functional dopaminergic deficit in the A53T-AAV synuclein rats by combining 6-[18F]fluoro-L-m-tyrosine imaging and motor performances analysis.

Journal: Neurobiology of aging

Published: November 19, 2019

Prevention of tau seeding and propagation by immunotherapy with a central tau epitope antibody.

Prevention of tau seeding and propagation by immunotherapy with a central tau epitope antibody.

Journal: Brain : a journal of neurology

Published: July 20, 2018

Engineering synucleinopathy-resistant human dopaminergic neurons by CRISPR-mediated deletion of the SNCA gene.

Engineering synucleinopathy-resistant human dopaminergic neurons by CRISPR-mediated deletion of the SNCA gene.

Journal: The European journal of neuroscience

Published: May 28, 2018

Epitope determines efficacy of therapeutic anti-Tau antibodies in a functional assay with human Alzheimer Tau.

Epitope determines efficacy of therapeutic anti-Tau antibodies in a functional assay with human Alzheimer Tau.

Journal: Acta neuropathologica

Published: April 23, 2018

Showing 1-12 of 17

Last Updated: 09/26/2026