Patrick F. Franken

Utrecht, UT, Netherlands

Last Updated: 09/26/2026

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Found 15 publications

Preclinical Comparison of Two CD3xB7H4 Bispecific Antibodies for Solid Tumor Therapy Reveals CD3 Affinity-Dependent Potency and Tolerability Tradeoffs.

Preclinical Comparison of Two CD3xB7H4 Bispecific Antibodies for Solid Tumor Therapy Reveals CD3 Affinity-Dependent Potency and Tolerability Tradeoffs.

Journal: Molecular cancer therapeutics

Published: January 13, 2026

Enapotamab Vedotin, an AXL-Specific Antibody-Drug Conjugate, Demonstrates Antitumor Efficacy in Patient-Derived Xenograft Models of Soft Tissue Sarcoma.

Enapotamab Vedotin, an AXL-Specific Antibody-Drug Conjugate, Demonstrates Antitumor Efficacy in Patient-Derived Xenograft Models of Soft Tissue Sarcoma.

Journal: International journal of molecular sciences

Published: May 30, 2022

Cooperative Targeting of Immunotherapy-Resistant Melanoma and Lung Cancer by an AXL-Targeting Antibody-Drug Conjugate and Immune Checkpoint Blockade.

Cooperative Targeting of Immunotherapy-Resistant Melanoma and Lung Cancer by an AXL-Targeting Antibody-Drug Conjugate and Immune Checkpoint Blockade.

Journal: Cancer research

Published: February 05, 2020

The role of S100a4 (Mts1) in Apc- and Smad4-driven tumour onset and progression.

The role of S100a4 (Mts1) in Apc- and Smad4-driven tumour onset and progression.

Journal: European journal of cancer (Oxford, England : 1990)

Published: June 30, 2016

Secreted Phospholipases A2 Are Intestinal Stem Cell Niche Factors with Distinct Roles in Homeostasis, Inflammation, and Cancer.

Secreted Phospholipases A2 Are Intestinal Stem Cell Niche Factors with Distinct Roles in Homeostasis, Inflammation, and Cancer.

Journal: Cell stem cell

Published: August 31, 2015

Cancer stemness in Wnt-driven mammary tumorigenesis.

Cancer stemness in Wnt-driven mammary tumorigenesis.

Journal: Carcinogenesis

Published: August 20, 2013

Wnt5a promotes human colon cancer cell migration and invasion but does not augment intestinal tumorigenesis in Apc1638N mice.

Wnt5a promotes human colon cancer cell migration and invasion but does not augment intestinal tumorigenesis in Apc1638N mice.

Journal: Carcinogenesis

Published: June 15, 2013

Cancer stemness in Apc- vs. Apc/KRAS-driven intestinal tumorigenesis.

Cancer stemness in Apc- vs. Apc/KRAS-driven intestinal tumorigenesis.

Journal: PloS one

Published: March 08, 2013

Alterations in Wnt-β-catenin and Pten signalling play distinct roles in endometrial cancer initiation and progression.

Alterations in Wnt-β-catenin and Pten signalling play distinct roles in endometrial cancer initiation and progression.

Journal: The Journal of pathology

Published: October 28, 2012

Wnt signaling regulates the lineage differentiation potential of mouse embryonic stem cells through Tcf3 down-regulation.

Wnt signaling regulates the lineage differentiation potential of mouse embryonic stem cells through Tcf3 down-regulation.

Journal: PLoS genetics

Published: August 02, 2012

β-Catenin signaling dosage dictates tissue-specific tumor predisposition in Apc-driven cancer.

β-Catenin signaling dosage dictates tissue-specific tumor predisposition in Apc-driven cancer.

Journal: Oncogene

Published: May 09, 2012

Paneth cells in intestinal homeostasis and tissue injury.

Paneth cells in intestinal homeostasis and tissue injury.

Journal: PloS one

Published: April 15, 2012

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Last Updated: 09/26/2026