Patrick H. Ehm

Hamburg, HH 20246, Germany

Last Updated: 09/26/2026

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Found 18 publications

Intra-subtype heterogeneity shapes treatment response in KMT2A-rearranged ALL across all age groups.

Intra-subtype heterogeneity shapes treatment response in KMT2A-rearranged ALL across all age groups.

Journal: HemaSphere

Published: August 14, 2025

The Inositol-5-Phosphatase SHIP1: Expression, Regulation and Role in Acute Lymphoblastic Leukemia.

The Inositol-5-Phosphatase SHIP1: Expression, Regulation and Role in Acute Lymphoblastic Leukemia.

Journal: International journal of molecular sciences

Published: June 19, 2025

Ikaros sets the threshold for negative B-cell selection by regulation of the signaling strength of the AKT pathway.

Ikaros sets the threshold for negative B-cell selection by regulation of the signaling strength of the AKT pathway.

Journal: Cell communication and signaling : CCS

Published: March 01, 2024

SHIP1 Is Present but Strongly Downregulated in T-ALL, and after Restoration Suppresses Leukemia Growth in a T-ALL Xenotransplantation Mouse Model.

SHIP1 Is Present but Strongly Downregulated in T-ALL, and after Restoration Suppresses Leukemia Growth in a T-ALL Xenotransplantation Mouse Model.

Journal: Cells

Published: May 25, 2023

Targeted hyperactivation of AKT through inhibition of ectopic expressed SHIP1 induces cell death in colon carcinoma cells and derived metastases.

Targeted hyperactivation of AKT through inhibition of ectopic expressed SHIP1 induces cell death in colon carcinoma cells and derived metastases.

Journal: Cellular signalling

Published: February 12, 2023

Activated Src kinases downstream of BCR-ABL and Flt3 induces proteasomal degradation of SHIP1 by phosphorylation of tyrosine 1021.

Activated Src kinases downstream of BCR-ABL and Flt3 induces proteasomal degradation of SHIP1 by phosphorylation of tyrosine 1021.

Journal: Biochimica et biophysica acta. Molecular cell research

Published: November 20, 2022

Reduced expression and activity of patient-derived SHIP1 phosphatase domain mutants.

Reduced expression and activity of patient-derived SHIP1 phosphatase domain mutants.

Journal: Cellular signalling

Published: March 23, 2022

JAK2-V617F is a negative regulation factor of SHIP1 protein and thus influences the AKT signaling pathway in patients with Myeloproliferative neoplasm (MPN).

JAK2-V617F is a negative regulation factor of SHIP1 protein and thus influences the AKT signaling pathway in patients with Myeloproliferative neoplasm (MPN).

Journal: The international journal of biochemistry & cell biology

Published: December 16, 2021

Investigation of the function of the PI3-Kinase / AKT signaling pathway for leukemogenesis and therapy of acute childhood lymphoblastic leukemia (ALL).

Investigation of the function of the PI3-Kinase / AKT signaling pathway for leukemogenesis and therapy of acute childhood lymphoblastic leukemia (ALL).

Journal: Cellular signalling

Published: December 09, 2021

Combined Targeting of AKT and mTOR Synergistically Inhibits Formation of Primary Colorectal Carcinoma Tumouroids In Vitro: A 3D Tumour Model for Pre-therapeutic Drug Screening.

Combined Targeting of AKT and mTOR Synergistically Inhibits Formation of Primary Colorectal Carcinoma Tumouroids In Vitro: A 3D Tumour Model for Pre-therapeutic Drug Screening.

Journal: Anticancer research

Published: March 12, 2021

Ectopic Expression of Hematopoietic SHIP1 in Human Colorectal Cancer.

Ectopic Expression of Hematopoietic SHIP1 in Human Colorectal Cancer.

Journal: Biomedicines

Published: May 19, 2020

Analysis of the FLVR motif of SHIP1 and its importance for the protein stability of SH2 containing signaling proteins.

Analysis of the FLVR motif of SHIP1 and its importance for the protein stability of SH2 containing signaling proteins.

Journal: Cellular signalling

Published: May 07, 2019

Showing 1-12 of 18

Last Updated: 09/26/2026