Paul A. Clarke

York, ENG YO105DD, United Kingdom

Last Updated: 09/26/2026

Save publications for later
Sign Up
Not sure about your diagnosis?
Check Your Symptoms
Found 79 publications

Fragment-Based Discovery of Potent RNA-Competitive Inhibitors of the DEAH-Box RNA Helicase DHX8.

Fragment-Based Discovery of Potent RNA-Competitive Inhibitors of the DEAH-Box RNA Helicase DHX8.

Journal: Journal of medicinal chemistry
Published: March 06, 2026

'Clip-Cycle' approaches to functionalised pyrrolidines, pyrrolizidines and indolizidines.

'Clip-Cycle' approaches to functionalised pyrrolidines, pyrrolizidines and indolizidines.

Journal: Organic & biomolecular chemistry
Published: December 18, 2025

Human DEAH-box helicase 8 regulates HSF1-mediated stress response and cancer-associated pre-mRNA splicing in tumour cells.

Human DEAH-box helicase 8 regulates HSF1-mediated stress response and cancer-associated pre-mRNA splicing in tumour cells.

Journal: NAR cancer
Published: September 25, 2025

Inhibition of cyclin-dependent kinase 8 modulates chondrocyte transition to hypertrophy and provides in vivo protection against spontaneous osteoarthritis.

Inhibition of cyclin-dependent kinase 8 modulates chondrocyte transition to hypertrophy and provides in vivo protection against spontaneous osteoarthritis.

Journal: Bone research
Published: August 21, 2025

Mediator Kinase Inhibitor Selectivity and Activity in Colorectal Cancer.

Mediator Kinase Inhibitor Selectivity and Activity in Colorectal Cancer.

Journal: ACS chemical biology
Published: July 02, 2025

R-loop editing by DNA cytosine deaminase APOBEC3B modulates the activity of oestrogen receptor enhancers.

R-loop editing by DNA cytosine deaminase APOBEC3B modulates the activity of oestrogen receptor enhancers.

Journal: Nature communications
Published: March 20, 2025

Asymmetric 'Clip-Cycle' synthesis of 3-spiropiperidines.

Asymmetric 'Clip-Cycle' synthesis of 3-spiropiperidines.

Journal: Organic & biomolecular chemistry
Published: November 26, 2024

Stereoselective synthesis of an advanced trans-decalin intermediate towards the total synthesis of anthracimycin.

Stereoselective synthesis of an advanced trans-decalin intermediate towards the total synthesis of anthracimycin.

Journal: Chemical communications (Cambridge, England)
Published: May 10, 2024

Structural insights into human brachyury DNA recognition and discovery of progressible binders for cancer therapy.

Structural insights into human brachyury DNA recognition and discovery of progressible binders for cancer therapy.

Journal: Nature communications
Published: May 09, 2024

Characterisation of APOBEC3B-Mediated RNA editing in breast cancer cells reveals regulatory roles of NEAT1 and MALAT1 lncRNAs.

Characterisation of APOBEC3B-Mediated RNA editing in breast cancer cells reveals regulatory roles of NEAT1 and MALAT1 lncRNAs.

Journal: Oncogene
Published: November 16, 2023

Integrating fragment-based screening with targeted protein degradation and genetic rescue to explore eIF4E function.

Integrating fragment-based screening with targeted protein degradation and genetic rescue to explore eIF4E function.

Journal: Nature communications
Published: September 21, 2023

HSF1 Pathway Inhibitor Clinical Candidate (CCT361814/NXP800) Developed from a Phenotypic Screen as a Potential Treatment for Refractory Ovarian Cancer and Other Malignancies.

HSF1 Pathway Inhibitor Clinical Candidate (CCT361814/NXP800) Developed from a Phenotypic Screen as a Potential Treatment for Refractory Ovarian Cancer and Other Malignancies.

Journal: Journal of medicinal chemistry
Published: April 05, 2023
Showing 1-12 of 79

Last Updated: 09/26/2026