Paul D. Brear

Cambridge, ENG, United Kingdom

Last Updated: 09/26/2026

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Found 49 publications

Targeting a Pleckstrin Homology Domain with a Lysine-Reactive Covalent Binder.

Targeting a Pleckstrin Homology Domain with a Lysine-Reactive Covalent Binder.

Journal: Journal of medicinal chemistry

Published: May 14, 2026

Yeast Display Technology Enables Rapid Discovery of Low-Nanomolar Macrocyclic Peptide Inhibitors of Human Angiotensin-Converting Enzyme 2.

Yeast Display Technology Enables Rapid Discovery of Low-Nanomolar Macrocyclic Peptide Inhibitors of Human Angiotensin-Converting Enzyme 2.

Journal: Journal of medicinal chemistry

Published: March 24, 2026

Selective Inhibition of CK2: Emerging Strategies and Future Directions.

Selective Inhibition of CK2: Emerging Strategies and Future Directions.

Journal: Journal of medicinal chemistry

Published: February 27, 2026

Utilizing Constrained Bicyclic Peptides for In Vitro Diagnostics.

Utilizing Constrained Bicyclic Peptides for In Vitro Diagnostics.

Journal: ACS nano

Published: February 13, 2026

Towards the targeted protein degradation of CK2: design and synthesis of CAM4066-based PROTACs.

Towards the targeted protein degradation of CK2: design and synthesis of CAM4066-based PROTACs.

Journal: Beilstein journal of organic chemistry

Published: January 10, 2026

An allantoin-inducible glyoxylate utilization pathway in Pseudomonas aeruginosa.

An allantoin-inducible glyoxylate utilization pathway in Pseudomonas aeruginosa.

Journal: Microbiology (Reading, England)

Published: December 10, 2025

Two birds with one stone: An antibiotic hit blocking Staphylococcus aureus heme uptake with serendipitous hemoglobin left-shifting activity.

Two birds with one stone: An antibiotic hit blocking Staphylococcus aureus heme uptake with serendipitous hemoglobin left-shifting activity.

Journal: iScience

Published: October 15, 2025

Exploiting the Cryptic αD Pocket of Casein Kinase 2α (CK2α) to Deliver Highly Potent and Selective Type 1 Inhibitors.

Exploiting the Cryptic αD Pocket of Casein Kinase 2α (CK2α) to Deliver Highly Potent and Selective Type 1 Inhibitors.

Journal: Journal of medicinal chemistry

Published: October 14, 2025

Potent Fluorescent Probe for Target-Engagement Studies of Allosteric Pyruvate Kinase Modulators.

Potent Fluorescent Probe for Target-Engagement Studies of Allosteric Pyruvate Kinase Modulators.

Journal: Angewandte Chemie (International ed. in English)

Published: June 26, 2025

The 2-methylcitrate cycle and the glyoxylate shunt in Pseudomonas aeruginosa are linked through enzymatic redundancy.

The 2-methylcitrate cycle and the glyoxylate shunt in Pseudomonas aeruginosa are linked through enzymatic redundancy.

Journal: The Journal of biological chemistry

Published: December 20, 2024

Pseudomonas aeruginosa PfpI is a methylglyoxalase.

Pseudomonas aeruginosa PfpI is a methylglyoxalase.

Journal: The Journal of biological chemistry

Published: December 06, 2024

Transcriptome-scale analysis uncovers conserved residues in the hydrophobic core of the bacterial RNA chaperone Hfq required for small regulatory RNA stability.

Transcriptome-scale analysis uncovers conserved residues in the hydrophobic core of the bacterial RNA chaperone Hfq required for small regulatory RNA stability.

Journal: Nucleic acids research

Published: September 30, 2024

Showing 1-12 of 49

Last Updated: 09/26/2026