Paul E. Sladen

34-38 Provost Street
London, ENG N17NG, United Kingdom

Last Updated: 09/26/2026

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Found 11 publications

KCNV2-Deficient Retinal Organoid Model of Cone Dystrophy-In Vitro Screening for AAV Gene Replacement Therapy.

KCNV2-Deficient Retinal Organoid Model of Cone Dystrophy-In Vitro Screening for AAV Gene Replacement Therapy.

Journal: International journal of molecular sciences

Published: November 13, 2025

Investigation of ABCA4 Missense Variants and Potential Small Molecule Rescue in Retinal Organoids.

Investigation of ABCA4 Missense Variants and Potential Small Molecule Rescue in Retinal Organoids.

Journal: Investigative ophthalmology & visual science

Published: July 22, 2025

CRISPRa-Mediated Increase of OPA1 Expression in Dominant Optic Atrophy.

CRISPRa-Mediated Increase of OPA1 Expression in Dominant Optic Atrophy.

Journal: International journal of molecular sciences

Published: May 23, 2025

Adenine base editor correction of pathogenic variations associated with inherited retinal dystrophy in patient iPSC and retinal organoids.

Adenine base editor correction of pathogenic variations associated with inherited retinal dystrophy in patient iPSC and retinal organoids.

Journal: Molecular therapy. Nucleic acids

Published: April 04, 2025

Disruption of mitochondrial homeostasis and permeability transition pore opening in OPA1 iPSC-derived retinal ganglion cells.

Disruption of mitochondrial homeostasis and permeability transition pore opening in OPA1 iPSC-derived retinal ganglion cells.

Journal: Acta neuropathologica communications

Published: September 25, 2024

AAV-RPGR Gene Therapy Rescues Opsin Mislocalisation in a Human Retinal Organoid Model of RPGR-Associated X-Linked Retinitis Pigmentosa.

AAV-RPGR Gene Therapy Rescues Opsin Mislocalisation in a Human Retinal Organoid Model of RPGR-Associated X-Linked Retinitis Pigmentosa.

Journal: International journal of molecular sciences

Published: December 05, 2023

Eupatilin improves cilia defects in human CEP290 ciliopathy models.

Eupatilin improves cilia defects in human CEP290 ciliopathy models.

Journal: bioRxiv : the preprint server for biology

Published: May 19, 2023

Eupatilin Improves Cilia Defects in Human CEP290 Ciliopathy Models.

Eupatilin Improves Cilia Defects in Human CEP290 Ciliopathy Models.

Journal: Cells

Published: April 06, 2023

Modelling autosomal dominant optic atrophy associated with OPA1 variants in iPSC-derived retinal ganglion cells.

Modelling autosomal dominant optic atrophy associated with OPA1 variants in iPSC-derived retinal ganglion cells.

Journal: Human molecular genetics

Published: April 04, 2022

Induced Pluripotent Stem Cells for Inherited Optic Neuropathies-Disease Modeling and Therapeutic Development.

Induced Pluripotent Stem Cells for Inherited Optic Neuropathies-Disease Modeling and Therapeutic Development.

Journal: Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society

Published: October 11, 2021

CRISPR-Cas9 correction of OPA1 c.1334G>A: p.R445H restores mitochondrial homeostasis in dominant optic atrophy patient-derived iPSCs.

CRISPR-Cas9 correction of OPA1 c.1334G>A: p.R445H restores mitochondrial homeostasis in dominant optic atrophy patient-derived iPSCs.

Journal: Molecular therapy. Nucleic acids

Published: October 28, 2020

Showing 1-11 of 11

Last Updated: 09/26/2026