Paul J. Whiting

UCL Queen Square Institute Of Neurology
London, ENG, United Kingdom

Last Updated: 09/26/2026

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Found 31 publications

Mutations in PSEN1 predispose inflammation in an astrocyte model of familial Alzheimer's disease through disrupted regulated intramembrane proteolysis.

Mutations in PSEN1 predispose inflammation in an astrocyte model of familial Alzheimer's disease through disrupted regulated intramembrane proteolysis.

Journal: Molecular neurodegeneration

Published: September 26, 2024

The hypermorphic PLCγ2 S707Y variant dysregulates microglial cell function - Insight into PLCγ2 activation in brain health and disease, and opportunities for therapeutic modulation.

The hypermorphic PLCγ2 S707Y variant dysregulates microglial cell function - Insight into PLCγ2 activation in brain health and disease, and opportunities for therapeutic modulation.

Journal: Biochimica et biophysica acta. Molecular basis of disease

Published: July 04, 2023

A multimodal screening platform for endogenous dipeptide repeat proteins in C9orf72 patient iPSC neurons.

A multimodal screening platform for endogenous dipeptide repeat proteins in C9orf72 patient iPSC neurons.

Journal: Cell reports

Published: June 21, 2023

A primary rodent triculture model to investigate the role of glia-neuron crosstalk in regulation of neuronal activity.

A primary rodent triculture model to investigate the role of glia-neuron crosstalk in regulation of neuronal activity.

Journal: Frontiers in aging neuroscience

Published: September 28, 2022

Microglial Expression of the Wnt Signaling Modulator DKK2 Differs between Human Alzheimer's Disease Brains and Mouse Neurodegeneration Models.

Microglial Expression of the Wnt Signaling Modulator DKK2 Differs between Human Alzheimer's Disease Brains and Mouse Neurodegeneration Models.

Journal: eNeuro

Published: July 25, 2022

Structural Analysis and Development of Notum Fragment Screening Hits.

Structural Analysis and Development of Notum Fragment Screening Hits.

Journal: ACS chemical neuroscience

Published: June 22, 2022

Design of a Potent, Selective, and Brain-Penetrant Inhibitor of Wnt-Deactivating Enzyme Notum by Optimization of a Crystallographic Fragment Hit.

Design of a Potent, Selective, and Brain-Penetrant Inhibitor of Wnt-Deactivating Enzyme Notum by Optimization of a Crystallographic Fragment Hit.

Journal: Journal of medicinal chemistry

Published: May 10, 2022

Alzheimer's Disease Enhanced Tonic Inhibition is Correlated With Upregulated Astrocyte GABA Transporter-3/4 in a Knock-In APP Mouse Model.

Alzheimer's Disease Enhanced Tonic Inhibition is Correlated With Upregulated Astrocyte GABA Transporter-3/4 in a Knock-In APP Mouse Model.

Journal: Frontiers in pharmacology

Published: November 25, 2021

Regulation of mitophagy by the NSL complex underlies genetic risk for Parkinson's disease at 16q11.2 and MAPT H1 loci.

Regulation of mitophagy by the NSL complex underlies genetic risk for Parkinson's disease at 16q11.2 and MAPT H1 loci.

Journal: Brain : a journal of neurology

Published: November 12, 2021

Epigenetic repression of Wnt receptors in AD: a role for Sirtuin2-induced H4K16ac deacetylation of Frizzled1 and Frizzled7 promoters.

Epigenetic repression of Wnt receptors in AD: a role for Sirtuin2-induced H4K16ac deacetylation of Frizzled1 and Frizzled7 promoters.

Journal: Molecular psychiatry

Published: July 05, 2021

Carboxylesterase Notum Is a Druggable Target to Modulate Wnt Signaling.

Carboxylesterase Notum Is a Druggable Target to Modulate Wnt Signaling.

Journal: Journal of medicinal chemistry

Published: March 30, 2021

5-Phenyl-1,3,4-oxadiazol-2(3H)-ones Are Potent Inhibitors of Notum Carboxylesterase Activity Identified by the Optimization of a Crystallographic Fragment Screening Hit.

5-Phenyl-1,3,4-oxadiazol-2(3H)-ones Are Potent Inhibitors of Notum Carboxylesterase Activity Identified by the Optimization of a Crystallographic Fragment Screening Hit.

Journal: Journal of medicinal chemistry

Published: October 30, 2020

Showing 1-12 of 31

Last Updated: 09/26/2026