Pavlina S. Konstantinova

Amsterdam, NH, Netherlands

Last Updated: 09/26/2026

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Found 30 publications

Systematic Review of the Huntington's Disease Drug Development Pipeline, 2014 to 2025.

Systematic Review of the Huntington's Disease Drug Development Pipeline, 2014 to 2025.

Journal: Movement disorders : official journal of the Movement Disorder Society

Published: July 15, 2025

A biological classification of Huntington's disease: the Integrated Staging System.

A biological classification of Huntington's disease: the Integrated Staging System.

Journal: The Lancet. Neurology

Published: August 09, 2021

PhP.B Enhanced Adeno-Associated Virus Mediated-Expression Following Systemic Delivery or Direct Brain Administration.

PhP.B Enhanced Adeno-Associated Virus Mediated-Expression Following Systemic Delivery or Direct Brain Administration.

Journal: Frontiers in bioengineering and biotechnology

Published: March 11, 2021

Transduction profiles in minipig following MRI guided delivery of AAV-5 into thalamic and corona radiata areas.

Transduction profiles in minipig following MRI guided delivery of AAV-5 into thalamic and corona radiata areas.

Journal: Journal of neuroscience methods

Published: February 12, 2021

Intrastriatal Administration of AAV5-miHTT in Non-Human Primates and Rats Is Well Tolerated and Results in miHTT Transgene Expression in Key Areas of Huntington Disease Pathology.

Intrastriatal Administration of AAV5-miHTT in Non-Human Primates and Rats Is Well Tolerated and Results in miHTT Transgene Expression in Key Areas of Huntington Disease Pathology.

Journal: Brain sciences

Published: November 27, 2020

Secreted therapeutics: monitoring durability of microRNA-based gene therapies in the central nervous system.

Secreted therapeutics: monitoring durability of microRNA-based gene therapies in the central nervous system.

Journal: Brain communications

Published: August 04, 2020

AAV5-miHTT gene therapy for Huntington disease: lowering both huntingtins.

AAV5-miHTT gene therapy for Huntington disease: lowering both huntingtins.

Journal: Expert opinion on biological therapy

Published: July 14, 2020

Gene Therapy for Neurodegenerative Diseases: Slowing Down the Ticking Clock.

Gene Therapy for Neurodegenerative Diseases: Slowing Down the Ticking Clock.

Journal: Frontiers in neuroscience

Published: July 05, 2020

Widespread and sustained target engagement in Huntington's disease minipigs upon intrastriatal microRNA-based gene therapy.

Widespread and sustained target engagement in Huntington's disease minipigs upon intrastriatal microRNA-based gene therapy.

Journal: Science translational medicine

Published: March 25, 2020

Cerebral Organoids: A Human Model for AAV Capsid Selection and Therapeutic Transgene Efficacy in the Brain.

Cerebral Organoids: A Human Model for AAV Capsid Selection and Therapeutic Transgene Efficacy in the Brain.

Journal: Molecular therapy. Methods & clinical development

Published: March 24, 2020

Transduction patterns in the CNS following various routes of AAV-5-mediated gene delivery.

Transduction patterns in the CNS following various routes of AAV-5-mediated gene delivery.

Journal: Gene therapy

Published: November 22, 2019

Development of an AAV-Based MicroRNA Gene Therapy to Treat Machado-Joseph Disease.

Development of an AAV-Based MicroRNA Gene Therapy to Treat Machado-Joseph Disease.

Journal: Molecular therapy. Methods & clinical development

Published: July 11, 2019

Showing 1-12 of 30

Last Updated: 09/26/2026