Peter J. Coombs

Stevenage, ENG SG12FX, United Kingdom

Last Updated: 09/26/2026

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Found 17 publications

Evaluating the druggability of TrmD, a potential antibacterial target, through design and microbiological profiling of a series of potent TrmD inhibitors.

Evaluating the druggability of TrmD, a potential antibacterial target, through design and microbiological profiling of a series of potent TrmD inhibitors.

Journal: Bioorganic & medicinal chemistry letters

Published: April 03, 2023

Identification, binding, and structural characterization of single domain anti-PD-L1 antibodies inhibitory of immune regulatory proteins PD-1 and CD80.

Identification, binding, and structural characterization of single domain anti-PD-L1 antibodies inhibitory of immune regulatory proteins PD-1 and CD80.

Journal: The Journal of biological chemistry

Published: August 30, 2022

Allosteric activation of MALT1 by its ubiquitin-binding Ig3 domain.

Allosteric activation of MALT1 by its ubiquitin-binding Ig3 domain.

Journal: Proceedings of the National Academy of Sciences of the United States of America

Published: January 26, 2020

Fragment-based target screening as an empirical approach to prioritising targets: a case study on antibacterials.

Fragment-based target screening as an empirical approach to prioritising targets: a case study on antibacterials.

Journal: Drug discovery today

Published: January 22, 2020

Potent bicyclic inhibitors of malarial cGMP-dependent protein kinase: approaches to combining improvements in cell potency, selectivity and structural novelty.

Potent bicyclic inhibitors of malarial cGMP-dependent protein kinase: approaches to combining improvements in cell potency, selectivity and structural novelty.

Journal: Bioorganic & medicinal chemistry letters

Published: July 01, 2019

Potent inhibitors of malarial P. Falciparum protein kinase G: Improving the cell activity of a series of imidazopyridines.

Potent inhibitors of malarial P. Falciparum protein kinase G: Improving the cell activity of a series of imidazopyridines.

Journal: Bioorganic & medicinal chemistry letters

Published: September 23, 2018

Characterization of Three Druggable Hot-Spots in the Aurora-A/TPX2 Interaction Using Biochemical, Biophysical, and Fragment-Based Approaches.

Characterization of Three Druggable Hot-Spots in the Aurora-A/TPX2 Interaction Using Biochemical, Biophysical, and Fragment-Based Approaches.

Journal: ACS chemical biology

Published: October 19, 2017

A potent series targeting the malarial cGMP-dependent protein kinase clears infection and blocks transmission.

A potent series targeting the malarial cGMP-dependent protein kinase clears infection and blocks transmission.

Journal: Nature communications

Published: February 20, 2017

Catechols and 3-hydroxypyridones as inhibitors of the DNA repair complex ERCC1-XPF.

Catechols and 3-hydroxypyridones as inhibitors of the DNA repair complex ERCC1-XPF.

Journal: Bioorganic & medicinal chemistry letters

Published: June 24, 2015

N-Hydroxyimides and hydroxypyrimidinones as inhibitors of the DNA repair complex ERCC1-XPF.

N-Hydroxyimides and hydroxypyrimidinones as inhibitors of the DNA repair complex ERCC1-XPF.

Journal: Bioorganic & medicinal chemistry letters

Published: June 24, 2015

Structural studies of postentry restriction factors reveal antiparallel dimers that enable avid binding to the HIV-1 capsid lattice.

Structural studies of postentry restriction factors reveal antiparallel dimers that enable avid binding to the HIV-1 capsid lattice.

Journal: Proceedings of the National Academy of Sciences of the United States of America

Published: July 01, 2014

Enhanced human receptor binding by H5 haemagglutinins.

Enhanced human receptor binding by H5 haemagglutinins.

Journal: Virology

Published: January 13, 2014

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Last Updated: 09/26/2026