Last Updated: 09/26/2026
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Found 12 publications
Gut-Restricted Selective Cyclooxygenase-2 (COX-2) Inhibitors for Chemoprevention of Colorectal Cancer.
Journal: Journal of medicinal chemistry
Published: July 19, 2021
Discovery of JNJ-63576253: A Clinical Stage Androgen Receptor Antagonist for F877L Mutant and Wild-Type Castration-Resistant Prostate Cancer (mCRPC).
Journal: Journal of medicinal chemistry
Published: January 20, 2021
Spirocyclic Thiohydantoin Antagonists of F877L and Wild-Type Androgen Receptor for Castration-Resistant Prostate Cancer.
Journal: ACS medicinal chemistry letters
Published: January 18, 2021
Discovery of JNJ-63576253, a Next-Generation Androgen Receptor Antagonist Active Against Wild-Type and Clinically Relevant Ligand Binding Domain Mutations in Metastatic Castration-Resistant Prostate Cancer.
Journal: Molecular cancer therapeutics
Published: June 18, 2020
AKR1C3 mediates pan-AR antagonist resistance in castration-resistant prostate cancer.
Journal: The Prostate
Published: May 25, 2020
The discovery of diazetidinyl diamides as potent and reversible inhibitors of monoacylglycerol lipase (MAGL).
Journal: Bioorganic & medicinal chemistry letters
Published: November 20, 2019
The discovery of azetidine-piperazine di-amides as potent, selective and reversible monoacylglycerol lipase (MAGL) inhibitors.
Journal: Bioorganic & medicinal chemistry letters
Published: November 20, 2019
Pharmacologic Characterization of JNJ-42226314, [1-(4-Fluorophenyl)indol-5-yl]-[3-[4-(thiazole-2-carbonyl)piperazin-1-yl]azetidin-1-yl]methanone, a Reversible, Selective, and Potent Monoacylglycerol Lipase Inhibitor.
Journal: The Journal of pharmacology and experimental therapeutics
Published: August 16, 2019
Discovery and optimization of a series of small-molecule allosteric inhibitors of MALT1 protease.
Journal: Bioorganic & medicinal chemistry letters
Published: March 13, 2019
Design and synthesis of a series of bioavailable fatty acid synthase (FASN) KR domain inhibitors for cancer therapy.
Journal: Bioorganic & medicinal chemistry letters
Published: April 03, 2018
Tetrahydroindazole derivatives as potent and peripherally selective cannabinoid-1 (CB1) receptor inverse agonists.
Journal: Bioorganic & medicinal chemistry letters
Published: August 03, 2016
A selective small molecule NOP (ORL-1 receptor) partial agonist for the treatment of anxiety.
Journal: Bioorganic & medicinal chemistry letters
Published: August 21, 2014
Showing 1-12 of 12
Last Updated: 09/26/2026