Petr Tomek

Auckland, AUK, New Zealand

Last Updated: 09/26/2026

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Found 16 publications

DJ-1 inhibition reshapes tumor microenvironment and potentiates immune checkpoint inhibitors.

DJ-1 inhibition reshapes tumor microenvironment and potentiates immune checkpoint inhibitors.

Journal: Science advances

Published: April 08, 2026

Synthesis and investigation of thieno[2,3-b]pyridines that restore activity of topotecan.

Synthesis and investigation of thieno[2,3-b]pyridines that restore activity of topotecan.

Journal: RSC medicinal chemistry

Published: June 06, 2025

N-formylkynurenine but not kynurenine enters a nucleophile-scavenging branch of the immune-regulatory kynurenine pathway.

N-formylkynurenine but not kynurenine enters a nucleophile-scavenging branch of the immune-regulatory kynurenine pathway.

Journal: Bioorganic chemistry

Published: December 11, 2024

Development of truncated Battacin antimicrobials featuring novel N-terminal fatty acids with an excellent safety profile.

Development of truncated Battacin antimicrobials featuring novel N-terminal fatty acids with an excellent safety profile.

Journal: Bioorganic & medicinal chemistry letters

Published: September 04, 2023

Evaluation of Novel Inhibitors of Tryptophan Dioxygenases for Enzyme and Species Selectivity Using Engineered Tumour Cell Lines Expressing Either Murine or Human IDO1 or TDO2.

Evaluation of Novel Inhibitors of Tryptophan Dioxygenases for Enzyme and Species Selectivity Using Engineered Tumour Cell Lines Expressing Either Murine or Human IDO1 or TDO2.

Journal: Pharmaceuticals (Basel, Switzerland)

Published: July 29, 2022

Conjugation of Palbociclib with MHI-148 Has an Increased Cytotoxic Effect for Breast Cancer Cells and an Altered Mechanism of Action.

Conjugation of Palbociclib with MHI-148 Has an Increased Cytotoxic Effect for Breast Cancer Cells and an Altered Mechanism of Action.

Journal: Molecules (Basel, Switzerland)

Published: November 25, 2021

Validating TDP1 as an Inhibition Target for the Development of Chemosensitizers for Camptothecin-Based Chemotherapy Drugs.

Validating TDP1 as an Inhibition Target for the Development of Chemosensitizers for Camptothecin-Based Chemotherapy Drugs.

Journal: Oncology and therapy

Published: May 07, 2021

Towards establishing extracellular vesicle-associated RNAs as biomarkers for HER2+ breast cancer.

Towards establishing extracellular vesicle-associated RNAs as biomarkers for HER2+ breast cancer.

Journal: F1000Research

Published: April 23, 2021

Parallel discovery of selective and dual inhibitors of tryptophan dioxygenases IDO1 and TDO2 with a newly-modified enzymatic assay.

Parallel discovery of selective and dual inhibitors of tryptophan dioxygenases IDO1 and TDO2 with a newly-modified enzymatic assay.

Journal: Bioorganic & medicinal chemistry

Published: February 23, 2021

Tryptophan: A Rheostat of Cancer Immune Escape Mediated by Immunosuppressive Enzymes IDO1 and TDO.

Tryptophan: A Rheostat of Cancer Immune Escape Mediated by Immunosuppressive Enzymes IDO1 and TDO.

Journal: Frontiers in immunology

Published: November 30, 2020

Discovery and Characterisation of Dual Inhibitors of Tryptophan 2,3-Dioxygenase (TDO2) and Indoleamine 2,3-Dioxygenase 1 (IDO1) Using Virtual Screening.

Discovery and Characterisation of Dual Inhibitors of Tryptophan 2,3-Dioxygenase (TDO2) and Indoleamine 2,3-Dioxygenase 1 (IDO1) Using Virtual Screening.

Journal: Molecules (Basel, Switzerland)

Published: October 30, 2019

Imprinted and ancient gene: a potential mediator of cancer cell survival during tryptophan deprivation.

Imprinted and ancient gene: a potential mediator of cancer cell survival during tryptophan deprivation.

Journal: Cell communication and signaling : CCS

Published: August 20, 2018

Showing 1-12 of 16

Last Updated: 09/26/2026