Philip A. Harris

Physiatry

1 Brookdale Plz
Brooklyn, NY 11212

Last Updated: 09/26/2026

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Found 23 publications

Inhibitors of RIP1 kinase: a patent review (2016-present).

Inhibitors of RIP1 kinase: a patent review (2016-present).

Journal: Expert opinion on therapeutic patents

Published: November 30, 2020

RIP1 Kinase Drives Macrophage-Mediated Adaptive Immune Tolerance in Pancreatic Cancer.

RIP1 Kinase Drives Macrophage-Mediated Adaptive Immune Tolerance in Pancreatic Cancer.

Journal: Cancer cell

Published: October 13, 2020

RIPK1 Mediates TNF-Induced Intestinal Crypt Apoptosis During Chronic NF-κB Activation.

RIPK1 Mediates TNF-Induced Intestinal Crypt Apoptosis During Chronic NF-κB Activation.

Journal: Cellular and molecular gastroenterology and hepatology

Published: June 07, 2019

Discovery and Lead-Optimization of 4,5-Dihydropyrazoles as Mono-Kinase Selective, Orally Bioavailable and Efficacious Inhibitors of Receptor Interacting Protein 1 (RIP1) Kinase.

Discovery and Lead-Optimization of 4,5-Dihydropyrazoles as Mono-Kinase Selective, Orally Bioavailable and Efficacious Inhibitors of Receptor Interacting Protein 1 (RIP1) Kinase.

Journal: Journal of medicinal chemistry

Published: April 24, 2019

Identification of a RIP1 Kinase Inhibitor Clinical Candidate (GSK3145095) for the Treatment of Pancreatic Cancer.

Identification of a RIP1 Kinase Inhibitor Clinical Candidate (GSK3145095) for the Treatment of Pancreatic Cancer.

Journal: ACS medicinal chemistry letters

Published: March 15, 2019

Elevated A20 promotes TNF-induced and RIPK1-dependent intestinal epithelial cell death.

Elevated A20 promotes TNF-induced and RIPK1-dependent intestinal epithelial cell death.

Journal: Proceedings of the National Academy of Sciences of the United States of America

Published: September 14, 2018

RIP1 Kinase Drives Macrophage-Mediated Adaptive Immune Tolerance in Pancreatic Cancer.

RIP1 Kinase Drives Macrophage-Mediated Adaptive Immune Tolerance in Pancreatic Cancer.

Journal: Cancer cell

Published: March 12, 2018

RIPK1 and Caspase-8 Ensure Chromosome Stability Independently of Their Role in Cell Death and Inflammation.

RIPK1 and Caspase-8 Ensure Chromosome Stability Independently of Their Role in Cell Death and Inflammation.

Journal: Molecular cell

Published: March 09, 2018

Identification of an antibody-based immunoassay for measuring direct target binding of RIPK1 inhibitors in cells and tissues.

Identification of an antibody-based immunoassay for measuring direct target binding of RIPK1 inhibitors in cells and tissues.

Journal: Pharmacology research & perspectives

Published: September 25, 2017

Randomized clinical study of safety, pharmacokinetics, and pharmacodynamics of RIPK1 inhibitor GSK2982772 in healthy volunteers.

Randomized clinical study of safety, pharmacokinetics, and pharmacodynamics of RIPK1 inhibitor GSK2982772 in healthy volunteers.

Journal: Pharmacology research & perspectives

Published: September 18, 2017

Autophagy protein ATG16L1 prevents necroptosis in the intestinal epithelium.

Autophagy protein ATG16L1 prevents necroptosis in the intestinal epithelium.

Journal: The Journal of experimental medicine

Published: March 28, 2017

Discovery of a First-in-Class Receptor Interacting Protein 1 (RIP1) Kinase Specific Clinical Candidate (GSK2982772) for the Treatment of Inflammatory Diseases.

Discovery of a First-in-Class Receptor Interacting Protein 1 (RIP1) Kinase Specific Clinical Candidate (GSK2982772) for the Treatment of Inflammatory Diseases.

Journal: Journal of medicinal chemistry

Published: February 03, 2017

Showing 1-12 of 23

Last Updated: 09/26/2026