Philip Seeman

1 King's College Circle
Toronto, ON, Canada

Last Updated: 09/26/2026

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Found 66 publications

The High Affinity Dopamine D2 Receptor Agonist MCL-536: A New Tool for Studying Dopaminergic Contribution to Neurological Disorders.

The High Affinity Dopamine D2 Receptor Agonist MCL-536: A New Tool for Studying Dopaminergic Contribution to Neurological Disorders.

Journal: ACS chemical neuroscience

Published: April 12, 2021

New Dopamine D2 Receptor Agonist, [3H]MCL-536, for Detecting Dopamine D2high Receptors in Vivo.

New Dopamine D2 Receptor Agonist, [3H]MCL-536, for Detecting Dopamine D2high Receptors in Vivo.

Journal: ACS chemical neuroscience

Published: April 12, 2018

Structural Investigation of the Dopamine-2 Receptor Agonist Bromocriptine Binding to Dimeric D2HighR and D2LowR States.

Structural Investigation of the Dopamine-2 Receptor Agonist Bromocriptine Binding to Dimeric D2HighR and D2LowR States.

Journal: Journal of chemical information and modeling

Published: March 15, 2018

Analysis of the Glutamate Agonist LY404,039 Binding to Nonstatic Dopamine Receptor D2 Dimer Structures and Consensus Docking.

Analysis of the Glutamate Agonist LY404,039 Binding to Nonstatic Dopamine Receptor D2 Dimer Structures and Consensus Docking.

Journal: ACS chemical neuroscience

Published: March 09, 2017

Biological Insights of the Dopaminergic Stabilizer ACR16 at the Binding Pocket of Dopamine D2 Receptor.

Biological Insights of the Dopaminergic Stabilizer ACR16 at the Binding Pocket of Dopamine D2 Receptor.

Journal: ACS chemical neuroscience

Published: December 22, 2016

The signaling pathway of dopamine D2 receptor (D2R) activation using normal mode analysis (NMA) and the construction of pharmacophore models for D2R ligands.

The signaling pathway of dopamine D2 receptor (D2R) activation using normal mode analysis (NMA) and the construction of pharmacophore models for D2R ligands.

Journal: Journal of biomolecular structure & dynamics

Published: July 02, 2016

Cannabidiol is a partial agonist at dopamine D2High receptors, predicting its antipsychotic clinical dose.

Cannabidiol is a partial agonist at dopamine D2High receptors, predicting its antipsychotic clinical dose.

Journal: Translational psychiatry

Published: May 11, 2016

Binding Interactions of Dopamine and Apomorphine in D2High and D2Low States of Human Dopamine D2 Receptor Using Computational and Experimental Techniques.

Binding Interactions of Dopamine and Apomorphine in D2High and D2Low States of Human Dopamine D2 Receptor Using Computational and Experimental Techniques.

Journal: ACS chemical neuroscience

Published: December 10, 2015

Glutamate drug reduces dopamine inhibition of phosphorylation.

Glutamate drug reduces dopamine inhibition of phosphorylation.

Journal: Synapse (New York, N.Y.)

Published: August 11, 2015

Misassembly of full-length Disrupted-in-Schizophrenia 1 protein is linked to altered dopamine homeostasis and behavioral deficits.

Misassembly of full-length Disrupted-in-Schizophrenia 1 protein is linked to altered dopamine homeostasis and behavioral deficits.

Journal: Molecular psychiatry

Published: November 14, 2014

Parkinson's disease treatment may cause impulse-control disorder via dopamine D3 receptors.

Parkinson's disease treatment may cause impulse-control disorder via dopamine D3 receptors.

Journal: Synapse (New York, N.Y.)

Published: November 11, 2014

Therapeutic occupation of dopamine D2 antipsychotic receptors in Alzheimer's disease.

Therapeutic occupation of dopamine D2 antipsychotic receptors in Alzheimer's disease.

Journal: International journal of geriatric psychiatry

Published: September 27, 2014

Showing 1-12 of 66

Last Updated: 09/26/2026