Philippe Roche

Marseille, France

Last Updated: 09/26/2026

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Found 40 publications

Engineering SIRPα conformational plasticity to reveal a cryptic pocket suitable for structure-based drug design.

Engineering SIRPα conformational plasticity to reveal a cryptic pocket suitable for structure-based drug design.

Journal: bioRxiv : the preprint server for biology

Published: January 07, 2026

NanoDSF Screening for Anti-tubulin Agents Uncovers New Structure-Activity Insights.

NanoDSF Screening for Anti-tubulin Agents Uncovers New Structure-Activity Insights.

Journal: Journal of medicinal chemistry

Published: August 15, 2025

How closely do ecosystem services and life cycle assessment frameworks concur when evaluating contrasting animal-production systems with ruminant or monogastric species?

How closely do ecosystem services and life cycle assessment frameworks concur when evaluating contrasting animal-production systems with ruminant or monogastric species?

Journal: Animal : an international journal of animal bioscience

Published: April 08, 2024

ChemoDOTS: a web server to design chemistry-driven focused libraries.

ChemoDOTS: a web server to design chemistry-driven focused libraries.

Journal: Nucleic acids research

Published: March 11, 2024

The Recurrent Liver MAN2A1-FER Oncoprotein Lacks Kinase Activity: Implications for the Use of Tyrosine Kinase Inhibitors.

The Recurrent Liver MAN2A1-FER Oncoprotein Lacks Kinase Activity: Implications for the Use of Tyrosine Kinase Inhibitors.

Journal: Cellular and molecular gastroenterology and hepatology

Published: December 04, 2023

Discovery of a PDZ Domain Inhibitor Targeting the Syndecan/Syntenin Protein-Protein Interaction: A Semi-Automated "Hit Identification-to-Optimization" Approach.

Discovery of a PDZ Domain Inhibitor Targeting the Syndecan/Syntenin Protein-Protein Interaction: A Semi-Automated "Hit Identification-to-Optimization" Approach.

Journal: Journal of medicinal chemistry

Published: March 20, 2023

Cinacalcet Reverses Short QT Interval in Familial Hypocalciuric Hypercalcemia Type 1.

Cinacalcet Reverses Short QT Interval in Familial Hypocalciuric Hypercalcemia Type 1.

Journal: The Journal of clinical endocrinology and metabolism

Published: January 30, 2023

From a drug repositioning to a structure-based drug design approach to tackle acute lymphoblastic leukemia.

From a drug repositioning to a structure-based drug design approach to tackle acute lymphoblastic leukemia.

Journal: Nature communications

Published: September 22, 2022

Discovery of Small-Molecule Inhibitors of the PTK7/β-Catenin Interaction Targeting the Wnt Signaling Pathway in Colorectal Cancer.

Discovery of Small-Molecule Inhibitors of the PTK7/β-Catenin Interaction Targeting the Wnt Signaling Pathway in Colorectal Cancer.

Journal: ACS chemical biology

Published: April 28, 2022

CRCM5484: A BET-BDII Selective Compound with Differential Anti-leukemic Drug Modulation.

CRCM5484: A BET-BDII Selective Compound with Differential Anti-leukemic Drug Modulation.

Journal: Journal of medicinal chemistry

Published: March 29, 2022

Rational Design of PDZ Domain Inhibitors: Discovery of Small Organic Compounds Targeting PDZ Domains.

Rational Design of PDZ Domain Inhibitors: Discovery of Small Organic Compounds Targeting PDZ Domains.

Journal: Methods in molecular biology (Clifton, N.J.)

Published: May 20, 2021

Fragment-based drug design targeting syntenin PDZ2 domain involved in exosomal release and tumour spread.

Fragment-based drug design targeting syntenin PDZ2 domain involved in exosomal release and tumour spread.

Journal: European journal of medicinal chemistry

Published: March 22, 2021

Showing 1-12 of 40

Last Updated: 09/26/2026