Philippe Sarret

3001 12e Avenue Nord
Sherbrooke, QC J1H5N4, Canada

Last Updated: 09/26/2026

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Found 115 publications

Structure-Guided Design of Proteomimetics Targeting the SARS-CoV-2 S-RBD/hACE2 Interface.

Structure-Guided Design of Proteomimetics Targeting the SARS-CoV-2 S-RBD/hACE2 Interface.

Journal: Journal of medicinal chemistry

Published: June 15, 2026

Improved brain penetration of neurotensin(8-13) via blood-brain barrier shuttle conjugation underlies strong analgesia.

Improved brain penetration of neurotensin(8-13) via blood-brain barrier shuttle conjugation underlies strong analgesia.

Journal: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Published: March 05, 2026

Dual-target opioid/neurotensin ligands drive potent and safer analgesia in vivo.

Dual-target opioid/neurotensin ligands drive potent and safer analgesia in vivo.

Journal: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Published: November 19, 2025

Structure-activity relationships of contulakin-G: Design, synthesis, and characterization of Thr10 analogs for pain modulation.

Structure-activity relationships of contulakin-G: Design, synthesis, and characterization of Thr10 analogs for pain modulation.

Journal: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Published: August 08, 2025

A neurotensin receptor type 1-derived pepducin acts as a biased allosteric modulator to regulate target receptor function.

A neurotensin receptor type 1-derived pepducin acts as a biased allosteric modulator to regulate target receptor function.

Journal: Acta pharmaceutica Sinica. B

Published: August 01, 2025

Docking of virtual libraries identifies small-molecule agonists of neurotensin receptors with analgesic activity.

Docking of virtual libraries identifies small-molecule agonists of neurotensin receptors with analgesic activity.

Journal: Nature communications

Published: April 15, 2025

Optimizing the pharmacokinetics and selectivity of TMPRSS2 inhibitors.

Optimizing the pharmacokinetics and selectivity of TMPRSS2 inhibitors.

Journal: European journal of medicinal chemistry

Published: February 18, 2025

Opioid Analgesics: Rise and Fall of Ligand Biased Signaling and Future Perspectives in the Quest for the Holy Grail.

Opioid Analgesics: Rise and Fall of Ligand Biased Signaling and Future Perspectives in the Quest for the Holy Grail.

Journal: CNS drugs

Published: February 16, 2025

A Metabolically Stable Apelin-13 Analog Acting as a Potent ITo Potassium Current Blocker with Potential Benefits for Brugada Syndrome.

A Metabolically Stable Apelin-13 Analog Acting as a Potent ITo Potassium Current Blocker with Potential Benefits for Brugada Syndrome.

Journal: International journal of molecular sciences

Published: February 11, 2025

A lipidated peptide derived from the C-terminal tail of the vasopressin 2 receptor shows promise as a new β-arrestin inhibitor.

A lipidated peptide derived from the C-terminal tail of the vasopressin 2 receptor shows promise as a new β-arrestin inhibitor.

Journal: Pharmacological research

Published: August 23, 2024

Structure-based design of macrocyclic peptides to generate functional antibodies against G protein-coupled receptors.

Structure-based design of macrocyclic peptides to generate functional antibodies against G protein-coupled receptors.

Journal: Nature communications

Published: August 16, 2024

Rational In Silico Design of Selective TMPRSS6 Peptidomimetic Inhibitors via Exploitation of the S2 Subpocket.

Rational In Silico Design of Selective TMPRSS6 Peptidomimetic Inhibitors via Exploitation of the S2 Subpocket.

Journal: Journal of medicinal chemistry

Published: July 19, 2024

Showing 1-12 of 115

Last Updated: 09/26/2026