Pierre Lestage

Croissy-sur-seine, 78290, France

Last Updated: 09/26/2026

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Found 11 publications

Development of Thiochroman Dioxide Analogues of Benzothiadiazine Dioxides as New Positive Allosteric Modulators of α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptors.

Development of Thiochroman Dioxide Analogues of Benzothiadiazine Dioxides as New Positive Allosteric Modulators of α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptors.

Journal: ACS chemical neuroscience

Published: July 09, 2021

New procognitive enhancers acting at the histamine H3 and AMPA receptors reverse natural forgetting in mice: comparisons with donepezil and memantine in the object recognition task.

New procognitive enhancers acting at the histamine H3 and AMPA receptors reverse natural forgetting in mice: comparisons with donepezil and memantine in the object recognition task.

Journal: Behavioural pharmacology

Published: November 30, 2018

Pharmacological characterisation of S 47445, a novel positive allosteric modulator of AMPA receptors.

Pharmacological characterisation of S 47445, a novel positive allosteric modulator of AMPA receptors.

Journal: PloS one

Published: May 30, 2017

In vivo pharmacological profile of S 38093, a novel histamine H3 receptor inverse agonist.

In vivo pharmacological profile of S 38093, a novel histamine H3 receptor inverse agonist.

Journal: European journal of pharmacology

Published: November 10, 2016

Mechanistic characterization of S 38093, a novel inverse agonist at histamine H3 receptors.

Mechanistic characterization of S 38093, a novel inverse agonist at histamine H3 receptors.

Journal: European journal of pharmacology

Published: November 10, 2016

Synthesis and Pharmacology of Mono-, Di-, and Trialkyl-Substituted 7-Chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-Dioxides Combined with X-ray Structure Analysis to Understand the Unexpected Structure-Activity Relationship at AMPA Receptors.

Synthesis and Pharmacology of Mono-, Di-, and Trialkyl-Substituted 7-Chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-Dioxides Combined with X-ray Structure Analysis to Understand the Unexpected Structure-Activity Relationship at AMPA Receptors.

Journal: ACS chemical neuroscience

Published: January 16, 2016

Thermodynamic characterization of new positive allosteric modulators binding to the glutamate receptor A2 ligand-binding domain: combining experimental and computational methods unravels differences in driving forces.

Thermodynamic characterization of new positive allosteric modulators binding to the glutamate receptor A2 ligand-binding domain: combining experimental and computational methods unravels differences in driving forces.

Journal: Journal of chemical information and modeling

Published: November 25, 2014

Positive allosteric modulators of 2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic acid receptors belonging to 4-cyclopropyl-3,4-dihydro-2h-1,2,4-pyridothiadiazine dioxides and diversely chloro-substituted 4-cyclopropyl-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxides.

Positive allosteric modulators of 2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic acid receptors belonging to 4-cyclopropyl-3,4-dihydro-2h-1,2,4-pyridothiadiazine dioxides and diversely chloro-substituted 4-cyclopropyl-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxides.

Journal: Journal of medicinal chemistry

Published: November 07, 2014

Synthesis, pharmacological and structural characterization, and thermodynamic aspects of GluA2-positive allosteric modulators with a 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide scaffold.

Synthesis, pharmacological and structural characterization, and thermodynamic aspects of GluA2-positive allosteric modulators with a 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide scaffold.

Journal: Journal of medicinal chemistry

Published: October 18, 2013

Development of thiophenic analogues of benzothiadiazine dioxides as new powerful potentiators of 2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic acid (AMPA) receptors.

Development of thiophenic analogues of benzothiadiazine dioxides as new powerful potentiators of 2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic acid (AMPA) receptors.

Journal: Journal of medicinal chemistry

Published: October 05, 2013

In vivo cross-sectional characterization of cerebral alterations induced by intracerebroventricular administration of streptozotocin.

In vivo cross-sectional characterization of cerebral alterations induced by intracerebroventricular administration of streptozotocin.

Journal: PloS one

Published: April 15, 2012

Showing 1-11 of 11

Last Updated: 09/26/2026