Pieter Leyssen

Leuven, VLG, Belgium

Last Updated: 09/26/2026

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Found 137 publications

A robust cell-based infection model for Rhinovirus C research and antiviral drug discovery.

A robust cell-based infection model for Rhinovirus C research and antiviral drug discovery.

Journal: Npj viruses

Published: February 19, 2026

Discovery and Preclinical Profile of ALG-097558, a Pan-Coronavirus 3CLpro Inhibitor.

Discovery and Preclinical Profile of ALG-097558, a Pan-Coronavirus 3CLpro Inhibitor.

Journal: Journal of medicinal chemistry

Published: June 30, 2025

High-throughput split-GFP antiviral screening assay against fusogenic paramyxoviruses.

High-throughput split-GFP antiviral screening assay against fusogenic paramyxoviruses.

Journal: Antiviral research

Published: May 27, 2025

Synthesis and antiviral activity of thiazolyl hydrazones against dengue virus.

Synthesis and antiviral activity of thiazolyl hydrazones against dengue virus.

Journal: Bioorganic & medicinal chemistry letters

Published: May 12, 2025

6-Chlorocoumarin Conjugates with Nucleobases and Nucleosides as Potent Anti-Hepatitis C Virus Agents.

6-Chlorocoumarin Conjugates with Nucleobases and Nucleosides as Potent Anti-Hepatitis C Virus Agents.

Journal: Molecules (Basel, Switzerland)

Published: February 22, 2025

Efficacy of Integrase Strand Transfer Inhibitors and the Capsid Inhibitor Lenacapavir against HIV-2, and Exploring the Effect of Raltegravir on the Activity of SARS-CoV-2.

Efficacy of Integrase Strand Transfer Inhibitors and the Capsid Inhibitor Lenacapavir against HIV-2, and Exploring the Effect of Raltegravir on the Activity of SARS-CoV-2.

Journal: Viruses

Published: September 05, 2024

PIP4K2C inhibition reverses autophagic flux impairment induced by SARS-CoV-2.

PIP4K2C inhibition reverses autophagic flux impairment induced by SARS-CoV-2.

Journal: Nature communications

Published: July 29, 2024

A coronavirus assembly inhibitor that targets the viral membrane protein.

A coronavirus assembly inhibitor that targets the viral membrane protein.

Journal: Nature

Published: April 06, 2024

A small-molecule SARS-CoV-2 inhibitor targeting the membrane protein.

A small-molecule SARS-CoV-2 inhibitor targeting the membrane protein.

Journal: Nature

Published: February 21, 2024

Design, synthesis, and lead optimization of piperazinyl-pyrimidine analogues as potent small molecules targeting the viral capping machinery of Chikungunya virus.

Design, synthesis, and lead optimization of piperazinyl-pyrimidine analogues as potent small molecules targeting the viral capping machinery of Chikungunya virus.

Journal: European journal of medicinal chemistry

Published: September 12, 2023

Broadly potent anti-SARS-CoV-2 antibody shares 93% of epitope with ACE2 and provides full protection in monkeys.

Broadly potent anti-SARS-CoV-2 antibody shares 93% of epitope with ACE2 and provides full protection in monkeys.

Journal: The Journal of infection

Published: July 31, 2023

Multiplexed multicolor antiviral assay amenable for high-throughput research.

Multiplexed multicolor antiviral assay amenable for high-throughput research.

Journal: Nature communications

Published: February 09, 2023

Showing 1-12 of 137

Last Updated: 09/26/2026