Pim A. Heckman
Maastricht, LI, Netherlands
Last Updated: 09/26/2026
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Found 30 publications
Application of the research domain criteria in early-phase clinical development of transdiagnostic neurotherapeutics: A multidisciplinary perspective.
Journal: Neuroscience applied
Published: November 22, 2025
Individual contribution of PDE4B and PDE4D subfamilies to the prevention of object location memory impairments induced by sleep deprivation.
Journal: Learning & memory (Cold Spring Harbor, N.Y.)
Published: February 18, 2025
Memory impairments observed after a half night sleep restriction are not mediated by working memory, attention, or inhibitory control mechanisms.
Journal: Neurobiology of learning and memory
Published: October 01, 2024
Treatment with the selective PDE4B inhibitor A-33 or PDE4D inhibitor zatolmilast prevents sleep deprivation-induced deficits in spatial pattern separation.
Journal: Behavioural brain research
Published: October 04, 2023
Acute sleep loss impairs object but not spatial pattern separation in humans.
Journal: Neuroscience letters
Published: June 21, 2023
Recovering object-location memories after sleep deprivation-induced amnesia.
Journal: Current biology : CB
Published: January 18, 2022
Soluble guanylate cyclase stimulator riociguat improves spatial memory in mice via peripheral mechanisms.
Journal: Neuroscience letters
Published: January 04, 2022
A brief period of sleep deprivation negatively impacts the acquisition, consolidation, and retrieval of object-location memories.
Journal: Neurobiology of learning and memory
Published: April 01, 2020
Genetic manipulation of cyclic nucleotide signaling during hippocampal neuroplasticity and memory formation.
Journal: Progress in neurobiology
Published: January 17, 2020
Phosphodiesterase inhibitors roflumilast and vardenafil prevent sleep deprivation-induced deficits in spatial pattern separation.
Journal: Synapse (New York, N.Y.)
Published: October 26, 2019
Role of cyclic nucleotides and their downstream signaling cascades in memory function: Being at the right time at the right spot.
Journal: Neuroscience and biobehavioral reviews
Published: September 10, 2019
Phosphodiesterase Type 4 Inhibition in CNS Diseases.
Journal: Trends in pharmacological sciences
Published: August 27, 2019
Last Updated: 09/26/2026