Pius O. Loetscher

Basel, BS 4002, Switzerland

Last Updated: 09/26/2026

Save publications for later

Sign Up

Not sure about your diagnosis?

Check Your Symptoms

Found 15 publications

Discovery of GJG057, a Potent and Highly Selective Inhibitor of Leukotriene C4 Synthase.

Discovery of GJG057, a Potent and Highly Selective Inhibitor of Leukotriene C4 Synthase.

Journal: Journal of medicinal chemistry

Published: February 17, 2025

Preclinical characterization of the Toll-like receptor 7/8 antagonist MHV370 for lupus therapy.

Preclinical characterization of the Toll-like receptor 7/8 antagonist MHV370 for lupus therapy.

Journal: Cell reports. Medicine

Published: September 21, 2022

Structure-Based Optimization of a Fragment-like TLR8 Binding Screening Hit to an In Vivo Efficacious TLR7/8 Antagonist.

Structure-Based Optimization of a Fragment-like TLR8 Binding Screening Hit to an In Vivo Efficacious TLR7/8 Antagonist.

Journal: ACS medicinal chemistry letters

Published: December 15, 2021

Nonhematopoietic IRAK1 drives arthritis via neutrophil chemoattractants.

Nonhematopoietic IRAK1 drives arthritis via neutrophil chemoattractants.

Journal: JCI insight

Published: March 22, 2021

Discovery of LYS006, a Potent and Highly Selective Inhibitor of Leukotriene A4 Hydrolase.

Discovery of LYS006, a Potent and Highly Selective Inhibitor of Leukotriene A4 Hydrolase.

Journal: Journal of medicinal chemistry

Published: February 16, 2021

Target-Based Identification and Optimization of 5-Indazol-5-yl Pyridones as Toll-like Receptor 7 and 8 Antagonists Using a Biochemical TLR8 Antagonist Competition Assay.

Target-Based Identification and Optimization of 5-Indazol-5-yl Pyridones as Toll-like Receptor 7 and 8 Antagonists Using a Biochemical TLR8 Antagonist Competition Assay.

Journal: Journal of medicinal chemistry

Published: August 14, 2020

RIPK3-MLKL-Mediated Neutrophil Death Requires Concurrent Activation of Fibroblast Activation Protein-α.

RIPK3-MLKL-Mediated Neutrophil Death Requires Concurrent Activation of Fibroblast Activation Protein-α.

Journal: Journal of immunology (Baltimore, Md. : 1950)

Published: January 31, 2020

The Proton-Sensing GPR4 Receptor Regulates Paracellular Gap Formation and Permeability of Vascular Endothelial Cells.

The Proton-Sensing GPR4 Receptor Regulates Paracellular Gap Formation and Permeability of Vascular Endothelial Cells.

Journal: iScience

Published: June 15, 2019

Pharmacological inhibition of GPR4 remediates intestinal inflammation in a mouse colitis model.

Pharmacological inhibition of GPR4 remediates intestinal inflammation in a mouse colitis model.

Journal: European journal of pharmacology

Published: November 24, 2018

Design and synthesis of potent and orally active GPR4 antagonists with modulatory effects on nociception, inflammation, and angiogenesis.

Design and synthesis of potent and orally active GPR4 antagonists with modulatory effects on nociception, inflammation, and angiogenesis.

Journal: Bioorganic & medicinal chemistry

Published: May 09, 2017

Development of Selective, Orally Active GPR4 Antagonists with Modulatory Effects on Nociception, Inflammation, and Angiogenesis.

Development of Selective, Orally Active GPR4 Antagonists with Modulatory Effects on Nociception, Inflammation, and Angiogenesis.

Journal: Journal of medicinal chemistry

Published: April 27, 2017

Pharmacological Blockade of the Chemokine Receptor CCR1 Protects Mice from Systemic Candidiasis of Hematogenous Origin.

Pharmacological Blockade of the Chemokine Receptor CCR1 Protects Mice from Systemic Candidiasis of Hematogenous Origin.

Journal: Antimicrobial agents and chemotherapy

Published: November 04, 2016

Showing 1-12 of 15

Last Updated: 09/26/2026