Prashant Khirsariya

St. Anne's University Hospital
Brno, JM 65691, Czech Republic

Last Updated: 09/26/2026

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Found 14 publications

Discovery of Two Structurally Distinct Classes of Inhibitors Targeting the Nuclease MUS81 and Enhancing Efficacy of Chemotherapy in Cancer Cells.

Discovery of Two Structurally Distinct Classes of Inhibitors Targeting the Nuclease MUS81 and Enhancing Efficacy of Chemotherapy in Cancer Cells.

Journal: Journal of medicinal chemistry

Published: February 25, 2026

CDK7-CDK11 axis in spliceosome regulation and pre-mRNA splicing.

CDK7-CDK11 axis in spliceosome regulation and pre-mRNA splicing.

Journal: Nucleic acids research

Published: March 30, 2025

Discovery of new inhibitors of nuclease MRE11.

Discovery of new inhibitors of nuclease MRE11.

Journal: European journal of medicinal chemistry

Published: May 28, 2024

Discovery of Potent and Exquisitely Selective Inhibitors of Kinase CK1 with Tunable Isoform Selectivity.

Discovery of Potent and Exquisitely Selective Inhibitors of Kinase CK1 with Tunable Isoform Selectivity.

Journal: Angewandte Chemie (International ed. in English)

Published: November 28, 2022

Synthesis and Profiling of Highly Selective Inhibitors of Methyltransferase DOT1L Based on Carbocyclic C-Nucleosides.

Synthesis and Profiling of Highly Selective Inhibitors of Methyltransferase DOT1L Based on Carbocyclic C-Nucleosides.

Journal: Journal of medicinal chemistry

Published: March 18, 2022

Cytoprotective activities of kinetin purine isosteres.

Cytoprotective activities of kinetin purine isosteres.

Journal: Bioorganic & medicinal chemistry

Published: December 02, 2020

The CHK1 inhibitor MU380 significantly increases the sensitivity of human docetaxel-resistant prostate cancer cells to gemcitabine through the induction of mitotic catastrophe.

The CHK1 inhibitor MU380 significantly increases the sensitivity of human docetaxel-resistant prostate cancer cells to gemcitabine through the induction of mitotic catastrophe.

Journal: Molecular oncology

Published: March 27, 2020

CDK12 controls G1/S progression by regulating RNAPII processivity at core DNA replication genes.

CDK12 controls G1/S progression by regulating RNAPII processivity at core DNA replication genes.

Journal: EMBO reports

Published: December 15, 2018

Novel CHK1 inhibitor MU380 exhibits significant single-agent activity in TP53-mutated chronic lymphocytic leukemia cells.

Novel CHK1 inhibitor MU380 exhibits significant single-agent activity in TP53-mutated chronic lymphocytic leukemia cells.

Journal: Haematologica

Published: July 31, 2018

Flow Cytometric Analysis of Nucleoside Transporters Activity in Chemoresistant Prostate Cancer Model.

Flow Cytometric Analysis of Nucleoside Transporters Activity in Chemoresistant Prostate Cancer Model.

Journal: Klinicka onkologie : casopis Ceske a Slovenske onkologicke spolecnosti

Published: May 29, 2018

Impact of the access tunnel engineering on catalysis is strictly ligand-specific.

Impact of the access tunnel engineering on catalysis is strictly ligand-specific.

Journal: The FEBS journal

Published: November 12, 2017

Chk1 Inhibitor SCH900776 Effectively Potentiates the Cytotoxic Effects of Platinum-Based Chemotherapeutic Drugs in Human Colon Cancer Cells.

Chk1 Inhibitor SCH900776 Effectively Potentiates the Cytotoxic Effects of Platinum-Based Chemotherapeutic Drugs in Human Colon Cancer Cells.

Journal: Neoplasia (New York, N.Y.)

Published: June 08, 2017

Showing 1-12 of 14

Last Updated: 09/26/2026