Pu Han

CAS Key Laboratory Of Pathogen Microbiology And Immunology
Beijing, China

Last Updated: 09/26/2026

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Found 34 publications

α-hemolysin targets LGALS3 (galectin 3) to promote intracellular survival of Staphylococcus aureus via lysosomal disruption and autophagy inhibition.

α-hemolysin targets LGALS3 (galectin 3) to promote intracellular survival of Staphylococcus aureus via lysosomal disruption and autophagy inhibition.

Journal: Autophagy

Published: March 06, 2026

Hemagglutinin double-mutation enhances binding of human-infecting avian influenza virus clade 2.3.4.4b H5Ny to human and SLeX receptors.

Hemagglutinin double-mutation enhances binding of human-infecting avian influenza virus clade 2.3.4.4b H5Ny to human and SLeX receptors.

Journal: EMBO reports

Published: December 09, 2025

Structure-guided discovery of a small molecule inhibitor of SARS-CoV-2 main protease with potent in vitro and in vivo antiviral activities.

Structure-guided discovery of a small molecule inhibitor of SARS-CoV-2 main protease with potent in vitro and in vivo antiviral activities.

Journal: Journal of virology

Published: November 14, 2025

Discovery of a potent covalent inhibitor that unusually distorts the catalytic dyad of SARS-CoV-2 main protease.

Discovery of a potent covalent inhibitor that unusually distorts the catalytic dyad of SARS-CoV-2 main protease.

Journal: Journal of virology

Published: September 15, 2025

From weak but broad to potent and universal: A trispecific antibody against conserved SARS-CoV-2 spike epitopes.

From weak but broad to potent and universal: A trispecific antibody against conserved SARS-CoV-2 spike epitopes.

Journal: Molecular therapy : the journal of the American Society of Gene Therapy

Published: August 08, 2025

Development of a trispecific fusion protein based on angiotensin-converting enzyme 2, glycoprotein 130, and tumor necrosis factor receptor 2 as a promising therapeutic for COVID-19.

Development of a trispecific fusion protein based on angiotensin-converting enzyme 2, glycoprotein 130, and tumor necrosis factor receptor 2 as a promising therapeutic for COVID-19.

Journal: Molecular biomedicine

Published: April 20, 2025

Cryo-EM structures of mycobacteria MmpL5-AcpM complex.

Cryo-EM structures of mycobacteria MmpL5-AcpM complex.

Journal: Science China. Life sciences

Published: April 15, 2025

Structural insight into GPR155-mediated cholesterol sensing and signal transduction.

Structural insight into GPR155-mediated cholesterol sensing and signal transduction.

Journal: Science bulletin

Published: February 10, 2025

Receptor binding, structure, and tissue tropism of cattle-infecting H5N1 avian influenza virus hemagglutinin.

Receptor binding, structure, and tissue tropism of cattle-infecting H5N1 avian influenza virus hemagglutinin.

Journal: Cell

Published: September 23, 2024

Assembly and breakage of head-to-head double hexamer reveals mpox virus E5-catalyzed DNA unwinding initiation.

Assembly and breakage of head-to-head double hexamer reveals mpox virus E5-catalyzed DNA unwinding initiation.

Journal: Nature communications

Published: August 22, 2024

Molecular basis of hippopotamus ACE2 binding to SARS-CoV-2.

Molecular basis of hippopotamus ACE2 binding to SARS-CoV-2.

Journal: Journal of virology

Published: April 09, 2024

Publisher Correction: Rational design of a 'two-in-one' immunogen DAM drives potent immune response against mpox virus.

Publisher Correction: Rational design of a 'two-in-one' immunogen DAM drives potent immune response against mpox virus.

Journal: Nature immunology

Published: January 15, 2024

Showing 1-12 of 34

Last Updated: 09/26/2026