Qidong H. You

Nanjing, 210009, China

Last Updated: 09/26/2026

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Found 222 publications

Modulating phosphorylation by proximity-inducing strategy: an update.

Modulating phosphorylation by proximity-inducing strategy: an update.

Journal: RSC medicinal chemistry

Published: June 09, 2026

Discovery of a Biased Kelch-like ECH-Associated Protein 1-p62 (Keap1-p62) Protein-Protein Interaction (PPI) Inhibitor for the Management of p62 Aberrant Hepatocellular Carcinoma.

Discovery of a Biased Kelch-like ECH-Associated Protein 1-p62 (Keap1-p62) Protein-Protein Interaction (PPI) Inhibitor for the Management of p62 Aberrant Hepatocellular Carcinoma.

Journal: Journal of medicinal chemistry

Published: May 30, 2026

Chaperones in kinase homeostasis and drug discovery.

Chaperones in kinase homeostasis and drug discovery.

Journal: Trends in pharmacological sciences

Published: May 12, 2026

Harnessing the E3 Ligase KLHL12 for Tumor-Selective Protein Degradation.

Harnessing the E3 Ligase KLHL12 for Tumor-Selective Protein Degradation.

Journal: Angewandte Chemie (International ed. in English)

Published: May 01, 2026

Development of highly selective, low-toxicity and orally available Mcl-1 inhibitors based on 3,5-dimethyl-4-sulfonimide-1H-pyrrole scaffold via P2/P3 dual pocket binding optimization.

Development of highly selective, low-toxicity and orally available Mcl-1 inhibitors based on 3,5-dimethyl-4-sulfonimide-1H-pyrrole scaffold via P2/P3 dual pocket binding optimization.

Journal: European journal of medicinal chemistry

Published: April 07, 2026

Protein tags facilitate the development of bifunctional molecules.

Protein tags facilitate the development of bifunctional molecules.

Journal: Drug discovery today

Published: March 24, 2026

Discovery of DDO-4279 as a PP5 degrader for the treatment of obesity.

Discovery of DDO-4279 as a PP5 degrader for the treatment of obesity.

Journal: RSC medicinal chemistry

Published: March 09, 2026

Repurposing Ilaprazole as a PP5 TPR Domain Binder with Modulatory Effects on MAPK Signaling.

Repurposing Ilaprazole as a PP5 TPR Domain Binder with Modulatory Effects on MAPK Signaling.

Journal: ACS medicinal chemistry letters

Published: February 02, 2026

Scaffold Hopping-Guided Design of Novel PIM-1 Inhibitors with Anticancer Activities.

Scaffold Hopping-Guided Design of Novel PIM-1 Inhibitors with Anticancer Activities.

Journal: Molecules (Basel, Switzerland)

Published: January 30, 2026

Nuclear factor erythroid 2-related factor 2 (Nrf2) inhibition revisited: advances and unmet challenges.

Nuclear factor erythroid 2-related factor 2 (Nrf2) inhibition revisited: advances and unmet challenges.

Journal: Journal of advanced research

Published: December 31, 2025

A Novel Paradigm for Targeting Challenging Targets: Advancing Technologies and Future Directions of Molecular Glue Degraders.

A Novel Paradigm for Targeting Challenging Targets: Advancing Technologies and Future Directions of Molecular Glue Degraders.

Journal: Molecules (Basel, Switzerland)

Published: December 19, 2025

Targeting Cyclic GMP-AMP Synthase: Novel Therapeutic Inhibitors for Autoimmune Diseases.

Targeting Cyclic GMP-AMP Synthase: Novel Therapeutic Inhibitors for Autoimmune Diseases.

Journal: ChemMedChem

Published: November 21, 2025

Showing 1-12 of 222

Last Updated: 09/26/2026