Qing-kun Shen

Key Laboratory Of Natural Medicines Of The Changbai Mountain
Longjing, 133002, China

Last Updated: 09/26/2026

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Found 56 publications

Amino acid fragment modification of natural products: Strategies for structural optimization, activity enhancement, and drug candidate potential improvement (2020-present).

Amino acid fragment modification of natural products: Strategies for structural optimization, activity enhancement, and drug candidate potential improvement (2020-present).

Journal: European journal of medicinal chemistry

Published: June 05, 2026

From inhibition to degradation: advances in highly selective targeting strategies for HPK1.

From inhibition to degradation: advances in highly selective targeting strategies for HPK1.

Journal: Molecular diversity

Published: May 15, 2026

Design synthesis and evaluation of usnic acid derivatives as multi-target drugs for Alzheimer's disease.

Design synthesis and evaluation of usnic acid derivatives as multi-target drugs for Alzheimer's disease.

Journal: Bioorganic chemistry

Published: March 31, 2026

Discovery of pyridine amide derivatives exhibiting vasodilatory activity.

Discovery of pyridine amide derivatives exhibiting vasodilatory activity.

Journal: Bioorganic chemistry

Published: March 12, 2026

Structural diversification and selective inhibition of HDAC3: A comprehensive review of inhibitors and degraders.

Structural diversification and selective inhibition of HDAC3: A comprehensive review of inhibitors and degraders.

Journal: European journal of medicinal chemistry

Published: January 19, 2026

Corrigendum to "Discovery of chalcone-1,2,4-triazole derivatives with potent anti-tumor activity targeting Bcl-2: In vitro and in vivo evaluation" [Bioorg. Chem. 169 (2026) 109371].

Corrigendum to "Discovery of chalcone-1,2,4-triazole derivatives with potent anti-tumor activity targeting Bcl-2: In vitro and in vivo evaluation" [Bioorg. Chem. 169 (2026) 109371].

Journal: Bioorganic chemistry

Published: January 13, 2026

Is it feasible for CDKs inhibitors to herald a new era in tackling the low sensitivity and drug resistance associated with PARP inhibitors?

Is it feasible for CDKs inhibitors to herald a new era in tackling the low sensitivity and drug resistance associated with PARP inhibitors?

Journal: Bioorganic chemistry

Published: November 17, 2025

Discovery of chalcone-1,2,4-triazole derivatives with potent anti-tumor activity targeting Bcl-2: In vitro and in vivo evaluation.

Discovery of chalcone-1,2,4-triazole derivatives with potent anti-tumor activity targeting Bcl-2: In vitro and in vivo evaluation.

Journal: Bioorganic chemistry

Published: September 30, 2025

Advances in mechanisms, combined therapeutic strategies and dual-target inhibitors for synergistic antitumor effects of HDAC and PD-1/PD-L1 pathway.

Advances in mechanisms, combined therapeutic strategies and dual-target inhibitors for synergistic antitumor effects of HDAC and PD-1/PD-L1 pathway.

Journal: Bioorganic chemistry

Published: September 25, 2025

Recent Advancements in Pentacyclic and Other Terpenoid Derivatives as Anti-inflammatory Agents.

Recent Advancements in Pentacyclic and Other Terpenoid Derivatives as Anti-inflammatory Agents.

Journal: Mini reviews in medicinal chemistry

Published: June 16, 2025

Discovery of oleanolic acid derivatives that inhibit tau protein phosphorylation and neuroinflammation induced by Aβ25-35 in vitro and in vivo.

Discovery of oleanolic acid derivatives that inhibit tau protein phosphorylation and neuroinflammation induced by Aβ25-35 in vitro and in vivo.

Journal: Bioorganic chemistry

Published: May 06, 2025

Advances in structural modification of natural products with antimicrobial activity.

Advances in structural modification of natural products with antimicrobial activity.

Journal: Fitoterapia

Published: April 19, 2025

Showing 1-12 of 56

Last Updated: 09/26/2026