Quentin Spillier

Brussels, BRU 1200, Belgium

Last Updated: 09/26/2026

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Found 13 publications

Structure-based design of stapled peptides targeting the oligomeric state of lactate dehydrogenase.

Structure-based design of stapled peptides targeting the oligomeric state of lactate dehydrogenase.

Journal: European journal of medicinal chemistry

Published: March 31, 2026

Unveiling the enzymatic activity of a dimeric LDH isoform and its implications for allosteric inhibition strategies.

Unveiling the enzymatic activity of a dimeric LDH isoform and its implications for allosteric inhibition strategies.

Journal: Protein science : a publication of the Protein Society

Published: July 01, 2025

Examining Arginase-1 Trimerization Uncovers a Promising Allosteric Site for Inhibition.

Examining Arginase-1 Trimerization Uncovers a Promising Allosteric Site for Inhibition.

Journal: Journal of medicinal chemistry

Published: January 03, 2025

Coenzyme Q headgroup intermediates can ameliorate a mitochondrial encephalopathy.

Coenzyme Q headgroup intermediates can ameliorate a mitochondrial encephalopathy.

Journal: Nature

Published: April 30, 2024

Tryptophan depletion sensitizes the AHR pathway by increasing AHR expression and GCN2/LAT1-mediated kynurenine uptake, and potentiates induction of regulatory T lymphocytes.

Tryptophan depletion sensitizes the AHR pathway by increasing AHR expression and GCN2/LAT1-mediated kynurenine uptake, and potentiates induction of regulatory T lymphocytes.

Journal: Journal for immunotherapy of cancer

Published: May 12, 2023

Phosphoglycerate dehydrogenase (PHGDH) inhibitors: a comprehensive review 2015-2020.

Phosphoglycerate dehydrogenase (PHGDH) inhibitors: a comprehensive review 2015-2020.

Journal: Expert opinion on therapeutic patents

Published: February 11, 2021

Unravelling the Allosteric Targeting of PHGDH at the ACT-Binding Domain with a Photoactivatable Diazirine Probe and Mass Spectrometry Experiments.

Unravelling the Allosteric Targeting of PHGDH at the ACT-Binding Domain with a Photoactivatable Diazirine Probe and Mass Spectrometry Experiments.

Journal: Molecules (Basel, Switzerland)

Published: December 31, 2020

The polar oxy-metabolome reveals the 4-hydroxymandelate CoQ10 synthesis pathway.

The polar oxy-metabolome reveals the 4-hydroxymandelate CoQ10 synthesis pathway.

Journal: Nature

Published: June 02, 2020

Interrogating the Lactate Dehydrogenase Tetramerization Site Using (Stapled) Peptides.

Interrogating the Lactate Dehydrogenase Tetramerization Site Using (Stapled) Peptides.

Journal: Journal of medicinal chemistry

Published: April 07, 2020

Structure-Activity Relationships (SARs) of α-Ketothioamides as Inhibitors of Phosphoglycerate Dehydrogenase (PHGDH).

Structure-Activity Relationships (SARs) of α-Ketothioamides as Inhibitors of Phosphoglycerate Dehydrogenase (PHGDH).

Journal: Pharmaceuticals (Basel, Switzerland)

Published: December 03, 2019

Anti-alcohol abuse drug disulfiram inhibits human PHGDH via disruption of its active tetrameric form through a specific cysteine oxidation.

Anti-alcohol abuse drug disulfiram inhibits human PHGDH via disruption of its active tetrameric form through a specific cysteine oxidation.

Journal: Scientific reports

Published: October 06, 2018

α-Ketothioamide Derivatives: A Promising Tool to Interrogate Phosphoglycerate Dehydrogenase (PHGDH).

α-Ketothioamide Derivatives: A Promising Tool to Interrogate Phosphoglycerate Dehydrogenase (PHGDH).

Journal: Journal of medicinal chemistry

Published: January 14, 2017

Showing 1-12 of 13

Last Updated: 09/26/2026