R L. Siegel-Krauth

Heidelberg, BW 69120, Germany

Last Updated: 09/26/2026

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Found 45 publications

In Vitro and In Silico Analysis of New n-Butyl and Isobutyl Quinoxaline-7-carboxylate 1,4-di-N-oxide Derivatives against Trypanosoma cruzi as Trypanothione Reductase Inhibitors.

In Vitro and In Silico Analysis of New n-Butyl and Isobutyl Quinoxaline-7-carboxylate 1,4-di-N-oxide Derivatives against Trypanosoma cruzi as Trypanothione Reductase Inhibitors.

Journal: International journal of molecular sciences

Published: August 30, 2022

Synthesis and Biological Evaluation of Natural-Product-Inspired, Aminoalkyl-Substituted 1-Benzopyrans as Novel Antiplasmodial Agents.

Synthesis and Biological Evaluation of Natural-Product-Inspired, Aminoalkyl-Substituted 1-Benzopyrans as Novel Antiplasmodial Agents.

Journal: Journal of medicinal chemistry

Published: April 26, 2021

The mitochondrial peroxiredoxin displays distinct roles in different developmental stages of African trypanosomes.

The mitochondrial peroxiredoxin displays distinct roles in different developmental stages of African trypanosomes.

Journal: Redox biology

Published: March 11, 2020

A tryparedoxin-coupled biosensor reveals a mitochondrial trypanothione metabolism in trypanosomes.

A tryparedoxin-coupled biosensor reveals a mitochondrial trypanothione metabolism in trypanosomes.

Journal: eLife

Published: October 31, 2019

Natural Sesquiterpene Lactones of the 4,15-iso-Atriplicolide Type are Inhibitors of Trypanothione Reductase.

Natural Sesquiterpene Lactones of the 4,15-iso-Atriplicolide Type are Inhibitors of Trypanothione Reductase.

Journal: Molecules (Basel, Switzerland)

Published: September 30, 2019

Targeting a Large Active Site: Structure-Based Design of Nanomolar Inhibitors of Trypanosoma brucei Trypanothione Reductase.

Targeting a Large Active Site: Structure-Based Design of Nanomolar Inhibitors of Trypanosoma brucei Trypanothione Reductase.

Journal: Chemistry (Weinheim an der Bergstrasse, Germany)

Published: April 10, 2019

An essential thioredoxin-type protein of Trypanosoma brucei acts as redox-regulated mitochondrial chaperone.

An essential thioredoxin-type protein of Trypanosoma brucei acts as redox-regulated mitochondrial chaperone.

Journal: PLoS pathogens

Published: March 26, 2019

Inhibitor-Induced Dimerization of an Essential Oxidoreductase from African Trypanosomes.

Inhibitor-Induced Dimerization of an Essential Oxidoreductase from African Trypanosomes.

Journal: Angewandte Chemie (International ed. in English)

Published: September 11, 2018

Tryparedoxin peroxidase-deficiency commits trypanosomes to ferroptosis-type cell death.

Tryparedoxin peroxidase-deficiency commits trypanosomes to ferroptosis-type cell death.

Journal: eLife

Published: April 12, 2018

Biological Evaluation and X-ray Co-crystal Structures of Cyclohexylpyrrolidine Ligands for Trypanothione Reductase, an Enzyme from the Redox Metabolism of Trypanosoma.

Biological Evaluation and X-ray Co-crystal Structures of Cyclohexylpyrrolidine Ligands for Trypanothione Reductase, an Enzyme from the Redox Metabolism of Trypanosoma.

Journal: ChemMedChem

Published: January 31, 2018

A glutaredoxin in the mitochondrial intermembrane space has stage-specific functions in the thermo-tolerance and proliferation of African trypanosomes.

A glutaredoxin in the mitochondrial intermembrane space has stage-specific functions in the thermo-tolerance and proliferation of African trypanosomes.

Journal: Redox biology

Published: December 28, 2017

Development of Novel Peptide-Based Michael Acceptors Targeting Rhodesain and Falcipain-2 for the Treatment of Neglected Tropical Diseases (NTDs).

Development of Novel Peptide-Based Michael Acceptors Targeting Rhodesain and Falcipain-2 for the Treatment of Neglected Tropical Diseases (NTDs).

Journal: Journal of medicinal chemistry

Published: August 02, 2017

Showing 1-12 of 45

Last Updated: 09/26/2026