Rachel M. Milne

Dow Street
Dundee, SCT DD15EH, United Kingdom

Last Updated: 09/26/2026

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Found 16 publications

Using Unbiased Chemical Proteomics Approaches to Explore the Target Landscape of the Resistance Refractory 7-Azaindole MMV022224 in Plasmodium falciparum.

Using Unbiased Chemical Proteomics Approaches to Explore the Target Landscape of the Resistance Refractory 7-Azaindole MMV022224 in Plasmodium falciparum.

Journal: ACS infectious diseases
Published: June 25, 2026

Discovery of 3-[(5-nitro-2-heteroaryl)methylene]-2-indolinone derivatives as highly potent antileishmanial agents and their bioactivation by NTR1 and 2.

Discovery of 3-[(5-nitro-2-heteroaryl)methylene]-2-indolinone derivatives as highly potent antileishmanial agents and their bioactivation by NTR1 and 2.

Journal: Bioorganic chemistry
Published: June 07, 2026

The Thienopyrimidinone Gamhépathiopine Targets the QO Site of Plasmodium falciparum Cytochrome b.

The Thienopyrimidinone Gamhépathiopine Targets the QO Site of Plasmodium falciparum Cytochrome b.

Journal: ACS infectious diseases
Published: June 03, 2025

ResMAP-a saturation mutagenesis platform enabling parallel profiling of target-specific resistance-conferring mutations in Plasmodium.

ResMAP-a saturation mutagenesis platform enabling parallel profiling of target-specific resistance-conferring mutations in Plasmodium.

Journal: mBio
Published: August 27, 2024

Chemical pulldown combined with mass spectrometry to identify the molecular targets of antimalarials in cell-free lysates.

Chemical pulldown combined with mass spectrometry to identify the molecular targets of antimalarials in cell-free lysates.

Journal: STAR protocols
Published: November 11, 2022

Antileishmanial Activities of (Z)-2-(Nitroimidazolylmethylene)-3(2H)-Benzofuranones: Synthesis, In Vitro Assessment, and Bioactivation by NTR 1 and 2.

Antileishmanial Activities of (Z)-2-(Nitroimidazolylmethylene)-3(2H)-Benzofuranones: Synthesis, In Vitro Assessment, and Bioactivation by NTR 1 and 2.

Journal: Antimicrobial agents and chemotherapy
Published: October 26, 2022

Toolkit of Approaches To Support Target-Focused Drug Discovery for Plasmodium falciparum Lysyl tRNA Synthetase.

Toolkit of Approaches To Support Target-Focused Drug Discovery for Plasmodium falciparum Lysyl tRNA Synthetase.

Journal: ACS infectious diseases
Published: August 29, 2022

High-Throughput Screening Platform To Identify Inhibitors of Protein Synthesis with Potential for the Treatment of Malaria.

High-Throughput Screening Platform To Identify Inhibitors of Protein Synthesis with Potential for the Treatment of Malaria.

Journal: Antimicrobial agents and chemotherapy
Published: June 01, 2022

Repositioning of a Diaminothiazole Series Confirmed to Target the Cyclin-Dependent Kinase CRK12 for Use in the Treatment of African Animal Trypanosomiasis.

Repositioning of a Diaminothiazole Series Confirmed to Target the Cyclin-Dependent Kinase CRK12 for Use in the Treatment of African Animal Trypanosomiasis.

Journal: Journal of medicinal chemistry
Published: March 18, 2022

Identification of a Proteasome-Targeting Arylsulfonamide with Potential for the Treatment of Chagas' Disease.

Identification of a Proteasome-Targeting Arylsulfonamide with Potential for the Treatment of Chagas' Disease.

Journal: Antimicrobial agents and chemotherapy
Published: October 04, 2021

An enhanced toolkit for the generation of knockout and marker-free fluorescent Plasmodium chabaudi.

An enhanced toolkit for the generation of knockout and marker-free fluorescent Plasmodium chabaudi.

Journal: Wellcome open research
Published: June 09, 2020

Potent acyl-CoA synthetase 10 inhibitors kill Plasmodium falciparum by disrupting triglyceride formation.

Potent acyl-CoA synthetase 10 inhibitors kill Plasmodium falciparum by disrupting triglyceride formation.

Journal: Nature communications
Published: June 05, 2020
Showing 1-12 of 16

Last Updated: 09/26/2026