Radek Indra

Charles University Albertov 6 128 00 Prague 2 Czech Republic
Prague, PR 12800, Czech Republic

Last Updated: 09/26/2026

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Found 27 publications

The relationship between cancer risk and cystic fibrosis: the role of CFTR in cell growth and cancer development.

The relationship between cancer risk and cystic fibrosis: the role of CFTR in cell growth and cancer development.

Journal: RSC medicinal chemistry

Published: March 06, 2025

The tyrosine kinase inhibitor lenvatinib is oxidized by rat cytochromes P450 and affects their expression in rat liver.

The tyrosine kinase inhibitor lenvatinib is oxidized by rat cytochromes P450 and affects their expression in rat liver.

Journal: Acta pharmaceutica (Zagreb, Croatia)

Published: June 20, 2024

The impact of individual human cytochrome P450 enzymes on oxidative metabolism of anticancer drug lenvatinib.

The impact of individual human cytochrome P450 enzymes on oxidative metabolism of anticancer drug lenvatinib.

Journal: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Published: September 03, 2021

Benzo[a]pyrene-Induced Genotoxicity in Rats Is Affected by Co-Exposure to Sudan I by Altering the Expression of Biotransformation Enzymes.

Benzo[a]pyrene-Induced Genotoxicity in Rats Is Affected by Co-Exposure to Sudan I by Altering the Expression of Biotransformation Enzymes.

Journal: International journal of molecular sciences

Published: June 25, 2021

Apoferritin/Vandetanib Association Is Long-Term Stable But Does Not Improve Pharmacological Properties of Vandetanib.

Apoferritin/Vandetanib Association Is Long-Term Stable But Does Not Improve Pharmacological Properties of Vandetanib.

Journal: International journal of molecular sciences

Published: February 08, 2021

Identification of Enzymes Oxidizing the Tyrosine Kinase Inhibitor Cabozantinib: Cabozantinib Is Predominantly Oxidized by CYP3A4 and Its Oxidation Is Stimulated by cyt b5 Activity.

Identification of Enzymes Oxidizing the Tyrosine Kinase Inhibitor Cabozantinib: Cabozantinib Is Predominantly Oxidized by CYP3A4 and Its Oxidation Is Stimulated by cyt b5 Activity.

Journal: Biomedicines

Published: October 20, 2020

Cytochrome P450 and flavin-containing monooxygenase enzymes are responsible for differential oxidation of the anti-thyroid-cancer drug vandetanib by human and rat hepatic microsomal systems.

Cytochrome P450 and flavin-containing monooxygenase enzymes are responsible for differential oxidation of the anti-thyroid-cancer drug vandetanib by human and rat hepatic microsomal systems.

Journal: Environmental toxicology and pharmacology

Published: August 02, 2019

The impact of p53 on aristolochic acid I-induced nephrotoxicity and DNA damage in vivo and in vitro.

The impact of p53 on aristolochic acid I-induced nephrotoxicity and DNA damage in vivo and in vitro.

Journal: Archives of toxicology

Published: July 16, 2019

Identification of Human Enzymes Oxidizing the Anti-Thyroid-Cancer Drug Vandetanib and Explanation of the High Efficiency of Cytochrome P450 3A4 in its Oxidation.

Identification of Human Enzymes Oxidizing the Anti-Thyroid-Cancer Drug Vandetanib and Explanation of the High Efficiency of Cytochrome P450 3A4 in its Oxidation.

Journal: International journal of molecular sciences

Published: June 18, 2019

Ellipticine-loaded apoferritin nanocarrier retains DNA adduct-based cytochrome P450-facilitated toxicity in neuroblastoma cells.

Ellipticine-loaded apoferritin nanocarrier retains DNA adduct-based cytochrome P450-facilitated toxicity in neuroblastoma cells.

Journal: Toxicology

Published: December 05, 2018

Application of hepatic cytochrome b5/P450 reductase null (HBRN) mice to study the role of cytochrome b5 in the cytochrome P450-mediated bioactivation of the anticancer drug ellipticine.

Application of hepatic cytochrome b5/P450 reductase null (HBRN) mice to study the role of cytochrome b5 in the cytochrome P450-mediated bioactivation of the anticancer drug ellipticine.

Journal: Toxicology and applied pharmacology

Published: November 04, 2018

Tyrosine kinase inhibitors vandetanib, lenvatinib and cabozantinib modulate oxidation of an anticancer agent ellipticine catalyzed by cytochromes P450 in vitro.

Tyrosine kinase inhibitors vandetanib, lenvatinib and cabozantinib modulate oxidation of an anticancer agent ellipticine catalyzed by cytochromes P450 in vitro.

Journal: Neuro endocrinology letters

Published: June 20, 2018

Showing 1-12 of 27

Last Updated: 09/26/2026