Rafael C. Gaspar

Limeira, SP, Brazil

Last Updated: 09/26/2026

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Found 59 publications

Precancer exercise capacity and metabolism during tumor development coordinate the skeletal muscle-tumor metabolic competition.

Precancer exercise capacity and metabolism during tumor development coordinate the skeletal muscle-tumor metabolic competition.

Journal: Proceedings of the National Academy of Sciences of the United States of America

Published: December 01, 2025

Hepatic ferredoxin reductase modulates mitochondrial function and iron homeostasis in metabolic dysfunction-associated steatotic liver disease.

Hepatic ferredoxin reductase modulates mitochondrial function and iron homeostasis in metabolic dysfunction-associated steatotic liver disease.

Journal: Research square

Published: September 05, 2025

Insulin receptorT1160 phosphorylation mediates renal cortical insulin resistance but not excess gluconeogenesis from glycerol.

Insulin receptorT1160 phosphorylation mediates renal cortical insulin resistance but not excess gluconeogenesis from glycerol.

Journal: Nature communications

Published: August 22, 2025

CIDEB and CGI-58 differentially regulate liver lipid-droplet cholesterol to modulate metabolic dysfunction-associated steatohepatitis severity.

CIDEB and CGI-58 differentially regulate liver lipid-droplet cholesterol to modulate metabolic dysfunction-associated steatohepatitis severity.

Journal: Cell reports

Published: July 24, 2025

Liver lipid droplet cholesterol content is a key determinant of metabolic dysfunction-associated steatohepatitis.

Liver lipid droplet cholesterol content is a key determinant of metabolic dysfunction-associated steatohepatitis.

Journal: Proceedings of the National Academy of Sciences of the United States of America

Published: May 01, 2025

Cideb knockdown in mice increases mitochondrial fat oxidation and reverses hepatic steatosis and insulin resistance by the plasma membrane sn-1,2-DAGs-PKCε-insulin receptor kinaseT1150 pathway.

Cideb knockdown in mice increases mitochondrial fat oxidation and reverses hepatic steatosis and insulin resistance by the plasma membrane sn-1,2-DAGs-PKCε-insulin receptor kinaseT1150 pathway.

Journal: Diabetologia

Published: March 27, 2025

Liver lipid droplet cholesterol content is a key determinant of metabolic dysfunction-associated steatohepatitis.

Liver lipid droplet cholesterol content is a key determinant of metabolic dysfunction-associated steatohepatitis.

Journal: bioRxiv : the preprint server for biology

Published: March 10, 2025

Western diet-induced MASH in PWK/PhJ mice identifies disruptions in amino acid and sphingolipid metabolism contributing to cardiac dysfunction.

Western diet-induced MASH in PWK/PhJ mice identifies disruptions in amino acid and sphingolipid metabolism contributing to cardiac dysfunction.

Journal: Nature communications

Published: February 25, 2025

Determinants of increased muscle insulin sensitivity of exercise-trained versus sedentary normal weight and overweight individuals.

Determinants of increased muscle insulin sensitivity of exercise-trained versus sedentary normal weight and overweight individuals.

Journal: Science advances

Published: January 01, 2025

Notch1 Signalling Is Downregulated by Aerobic Exercise, Leading to Improvement of Hepatic Metabolism in Obese Mice.

Notch1 Signalling Is Downregulated by Aerobic Exercise, Leading to Improvement of Hepatic Metabolism in Obese Mice.

Journal: Liver international : official journal of the International Association for the Study of the Liver

Published: November 01, 2024

Time-restricted feeding reduces inflammatory markers and downregulates JAG1 and NICD protein levels in the liver of aged mice.

Time-restricted feeding reduces inflammatory markers and downregulates JAG1 and NICD protein levels in the liver of aged mice.

Journal: Nutrition (Burbank, Los Angeles County, Calif.)

Published: October 14, 2024

Small molecule inhibition of glycogen synthase I reduces muscle glycogen content and improves biomarkers in a mouse model of Pompe disease.

Small molecule inhibition of glycogen synthase I reduces muscle glycogen content and improves biomarkers in a mouse model of Pompe disease.

Journal: American journal of physiology. Endocrinology and metabolism

Published: August 22, 2024

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Last Updated: 09/26/2026