Ralf-dieter D. Hilgers

Aachen, NW, Germany

Last Updated: 09/26/2026

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Found 90 publications

When randomization is not random: Allocation bias in small sample, group sequential randomized clinical trials.

When randomization is not random: Allocation bias in small sample, group sequential randomized clinical trials.

Journal: Statistical methods in medical research

Published: April 30, 2026

Longitudinal progression, metrics, age-dependence, and modifiers of ataxia severity in SCA27B: a multicentre study of 219 patients.

Longitudinal progression, metrics, age-dependence, and modifiers of ataxia severity in SCA27B: a multicentre study of 219 patients.

Journal: EBioMedicine

Published: November 03, 2025

Assessing allocation bias in stratified clinical trials with multi-component endpoints evaluated using the stratified Wei-Lachin test.

Assessing allocation bias in stratified clinical trials with multi-component endpoints evaluated using the stratified Wei-Lachin test.

Journal: PloS one

Published: September 16, 2025

Does randomization matter in rare disease clinical trials.

Does randomization matter in rare disease clinical trials.

Journal: PloS one

Published: July 24, 2025

Analysis of a Modified Version of the Inventory of Non-Ataxia Signs Over 12 Years in Patients with Friedreich's Ataxia in the EFACTS Study.

Analysis of a Modified Version of the Inventory of Non-Ataxia Signs Over 12 Years in Patients with Friedreich's Ataxia in the EFACTS Study.

Journal: Movement disorders : official journal of the Movement Disorder Society

Published: May 16, 2025

Scoliosis Surgery in a Patient With Advanced Friedreich's Ataxia-It Is Not Too Late.

Scoliosis Surgery in a Patient With Advanced Friedreich's Ataxia-It Is Not Too Late.

Journal: Annals of clinical and translational neurology

Published: April 17, 2025

A Pharmacometrics-Informed Trial Simulation Framework for Optimizing Study Designs for Disease-Modifying Treatments in Rare Neurological Disorders.

A Pharmacometrics-Informed Trial Simulation Framework for Optimizing Study Designs for Disease-Modifying Treatments in Rare Neurological Disorders.

Journal: CPT: pharmacometrics & systems pharmacology

Published: February 28, 2025

Optimising clinical trial methods for complex regional pain syndrome: a methodological framework (OptiMeth-CRPS).

Optimising clinical trial methods for complex regional pain syndrome: a methodological framework (OptiMeth-CRPS).

Journal: Pain reports

Published: January 08, 2025

Randomization in clinical trials with small sample sizes using group sequential designs.

Randomization in clinical trials with small sample sizes using group sequential designs.

Journal: PloS one

Published: November 27, 2024

Multi-stakeholder sessions on major innovation topics in rare disease clinical trials.

Multi-stakeholder sessions on major innovation topics in rare disease clinical trials.

Journal: Orphanet journal of rare diseases

Published: August 19, 2024

The effectiveness of the UniReliever offloading knee brace for treating medial knee osteoarthritis: A randomized clinical trial.

The effectiveness of the UniReliever offloading knee brace for treating medial knee osteoarthritis: A randomized clinical trial.

Journal: Prosthetics and orthotics international

Published: August 19, 2024

Methodological insights from the EPISTOP trial to designing clinical trials in rare diseases-A secondary analysis of a randomized clinical trial.

Methodological insights from the EPISTOP trial to designing clinical trials in rare diseases-A secondary analysis of a randomized clinical trial.

Journal: PloS one

Published: June 21, 2024

Showing 1-12 of 90

Last Updated: 09/26/2026