Ralph D. Hector

Edinburgh, SCT EH89XD, United Kingdom

Last Updated: 09/26/2026

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Found 21 publications

FMR1 gene therapy restores activity-driven inhibition and prevents audiogenic seizures in Fmr1 -/y mice.

FMR1 gene therapy restores activity-driven inhibition and prevents audiogenic seizures in Fmr1 -/y mice.

Journal: bioRxiv : the preprint server for biology

Published: June 29, 2026

Neonatal expression of human FMRP isoform corrects cortical deficits and improves behavior in a mouse model of fragile X syndrome.

Neonatal expression of human FMRP isoform corrects cortical deficits and improves behavior in a mouse model of fragile X syndrome.

Journal: Molecular therapy. Nucleic acids

Published: April 01, 2026

Self-regulating gene therapy ameliorates phenotypes and overcomes gene dosage sensitivity in a mouse model of Rett syndrome.

Self-regulating gene therapy ameliorates phenotypes and overcomes gene dosage sensitivity in a mouse model of Rett syndrome.

Journal: Science translational medicine

Published: April 02, 2025

Deletions in the CDKL5 5' untranslated region lead to CDKL5 deficiency disorder.

Deletions in the CDKL5 5' untranslated region lead to CDKL5 deficiency disorder.

Journal: American journal of medical genetics. Part A

Published: May 14, 2024

Molecular Characterisation of Equine Herpesvirus 1 Isolates from Cases of Abortion, Respiratory and Neurological Disease in Ireland between 1990 and 2017.

Molecular Characterisation of Equine Herpesvirus 1 Isolates from Cases of Abortion, Respiratory and Neurological Disease in Ireland between 1990 and 2017.

Journal: Pathogens (Basel, Switzerland)

Published: December 17, 2018

A kinome-wide screen identifies a CDKL5-SOX9 regulatory axis in epithelial cell death and kidney injury.

A kinome-wide screen identifies a CDKL5-SOX9 regulatory axis in epithelial cell death and kidney injury.

Journal: Nature communications

Published: November 10, 2018

Equid herpesvirus 8: Complete genome sequence and association with abortion in mares.

Equid herpesvirus 8: Complete genome sequence and association with abortion in mares.

Journal: PloS one

Published: October 26, 2017

CDKL5 variants: Improving our understanding of a rare neurologic disorder.

CDKL5 variants: Improving our understanding of a rare neurologic disorder.

Journal: Neurology. Genetics

Published: May 02, 2017

Radically truncated MeCP2 rescues Rett syndrome-like neurological defects.

Radically truncated MeCP2 rescues Rett syndrome-like neurological defects.

Journal: Nature

Published: March 29, 2017

Improved MECP2 Gene Therapy Extends the Survival of MeCP2-Null Mice without Apparent Toxicity after Intracisternal Delivery.

Improved MECP2 Gene Therapy Extends the Survival of MeCP2-Null Mice without Apparent Toxicity after Intracisternal Delivery.

Journal: Molecular therapy. Methods & clinical development

Published: February 24, 2017

Development of a Novel AAV Gene Therapy Cassette with Improved Safety Features and Efficacy in a Mouse Model of Rett Syndrome.

Development of a Novel AAV Gene Therapy Cassette with Improved Safety Features and Efficacy in a Mouse Model of Rett Syndrome.

Journal: Molecular therapy. Methods & clinical development

Published: February 24, 2017

Characterisation of Cdkl5 transcript isoforms in rat.

Characterisation of Cdkl5 transcript isoforms in rat.

Journal: Gene

Published: September 28, 2016

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Last Updated: 09/26/2026