Raphaelle Lesage

Leuven, VLG, Belgium

Last Updated: 09/26/2026

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Found 11 publications

A multiscale modeling approach to study the role of mechanics and inflammation in the pathophysiology of articular cartilage.

A multiscale modeling approach to study the role of mechanics and inflammation in the pathophysiology of articular cartilage.

Journal: Computers in biology and medicine
Published: December 30, 2025

A multi-model approach identifies ALW-II-41-27 as a promising therapy for osteoarthritis-associated inflammation and endochondral ossification.

A multi-model approach identifies ALW-II-41-27 as a promising therapy for osteoarthritis-associated inflammation and endochondral ossification.

Journal: Heliyon
Published: June 24, 2024

Mapping the use of computational modelling and simulation in clinics: A survey.

Mapping the use of computational modelling and simulation in clinics: A survey.

Journal: Frontiers in medical technology
Published: December 16, 2022

An integrated in silico-in vitro approach for identifying therapeutic targets against osteoarthritis.

An integrated in silico-in vitro approach for identifying therapeutic targets against osteoarthritis.

Journal: BMC biology
Published: January 28, 2022

Human pluripotent stem cell-derived cartilaginous organoids promote scaffold-free healing of critical size long bone defects.

Human pluripotent stem cell-derived cartilaginous organoids promote scaffold-free healing of critical size long bone defects.

Journal: Stem cell research & therapy
Published: March 12, 2021

Scientific and regulatory evaluation of mechanistic in silico drug and disease models in drug development: Building model credibility.

Scientific and regulatory evaluation of mechanistic in silico drug and disease models in drug development: Building model credibility.

Journal: CPT: pharmacometrics & systems pharmacology
Published: February 08, 2021

Dissecting the effects of preconditioning with inflammatory cytokines and hypoxia on the angiogenic potential of mesenchymal stromal cell (MSC)-derived soluble proteins and extracellular vesicles (EVs).

Dissecting the effects of preconditioning with inflammatory cytokines and hypoxia on the angiogenic potential of mesenchymal stromal cell (MSC)-derived soluble proteins and extracellular vesicles (EVs).

Journal: Biomaterials
Published: August 18, 2020

Turning Nature's own processes into design strategies for living bone implant biomanufacturing: a decade of Developmental Engineering.

Turning Nature's own processes into design strategies for living bone implant biomanufacturing: a decade of Developmental Engineering.

Journal: Advanced drug delivery reviews
Published: May 16, 2020

Verifying and Validating Quantitative Systems Pharmacology and In Silico Models in Drug Development: Current Needs, Gaps, and Challenges.

Verifying and Validating Quantitative Systems Pharmacology and In Silico Models in Drug Development: Current Needs, Gaps, and Challenges.

Journal: CPT: pharmacometrics & systems pharmacology
Published: January 03, 2020

Computational Modeling and Reverse Engineering to Reveal Dominant Regulatory Interactions Controlling Osteochondral Differentiation: Potential for Regenerative Medicine.

Computational Modeling and Reverse Engineering to Reveal Dominant Regulatory Interactions Controlling Osteochondral Differentiation: Potential for Regenerative Medicine.

Journal: Frontiers in bioengineering and biotechnology
Published: March 01, 2018

Discrete adipose-derived stem cell subpopulations may display differential functionality after in vitro expansion despite convergence to a common phenotype distribution.

Discrete adipose-derived stem cell subpopulations may display differential functionality after in vitro expansion despite convergence to a common phenotype distribution.

Journal: Stem cell research & therapy
Published: July 12, 2016
Showing 1-11 of 11

Last Updated: 09/26/2026