Rebecca J. Fairclough

BioPharmaceuticals R&D, AstraZeneca
Cambridge, ENG, United Kingdom

Last Updated: 09/26/2026

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Found 12 publications

Compromised chronic efficacy of a glucokinase activator AZD1656 in mouse models for common human GCKR variants.

Compromised chronic efficacy of a glucokinase activator AZD1656 in mouse models for common human GCKR variants.

Journal: Biochemical pharmacology

Published: May 15, 2024

The GCKR-P446L gene variant predisposes to raised blood cholesterol and lower blood glucose in the P446L mouse-a model for GCKR rs1260326.

The GCKR-P446L gene variant predisposes to raised blood cholesterol and lower blood glucose in the P446L mouse-a model for GCKR rs1260326.

Journal: Molecular metabolism

Published: March 07, 2023

Clinic-ready inhibitor of MMP-9/-12 restores sensory and functional decline in rodent models of spinal cord injury.

Clinic-ready inhibitor of MMP-9/-12 restores sensory and functional decline in rodent models of spinal cord injury.

Journal: Clinical and translational medicine

Published: April 05, 2022

Oral 11β-HSD1 inhibitor AZD4017 improves wound healing and skin integrity in adults with type 2 diabetes mellitus: a pilot randomized controlled trial.

Oral 11β-HSD1 inhibitor AZD4017 improves wound healing and skin integrity in adults with type 2 diabetes mellitus: a pilot randomized controlled trial.

Journal: European journal of endocrinology

Published: November 30, 2021

Effect of AZD4017, a Selective 11β-HSD1 Inhibitor, on Bone Turnover Markers in Postmenopausal Osteopenia.

Effect of AZD4017, a Selective 11β-HSD1 Inhibitor, on Bone Turnover Markers in Postmenopausal Osteopenia.

Journal: The Journal of clinical endocrinology and metabolism

Published: October 18, 2021

Public-Private Partnerships: Compound and Data Sharing in Drug Discovery and Development.

Public-Private Partnerships: Compound and Data Sharing in Drug Discovery and Development.

Journal: SLAS discovery : advancing life sciences R & D

Published: February 15, 2021

Discovery and mechanism of action studies of 4,6-diphenylpyrimidine-2-carbohydrazides as utrophin modulators for the treatment of Duchenne muscular dystrophy.

Discovery and mechanism of action studies of 4,6-diphenylpyrimidine-2-carbohydrazides as utrophin modulators for the treatment of Duchenne muscular dystrophy.

Journal: European journal of medicinal chemistry

Published: December 01, 2020

11βHSD1 Inhibition with AZD4017 Improves Lipid Profiles and Lean Muscle Mass in Idiopathic Intracranial Hypertension.

11βHSD1 Inhibition with AZD4017 Improves Lipid Profiles and Lean Muscle Mass in Idiopathic Intracranial Hypertension.

Journal: The Journal of clinical endocrinology and metabolism

Published: June 15, 2020

Chronic glucokinase activator treatment activates liver Carbohydrate response element binding protein and improves hepatocyte ATP homeostasis during substrate challenge.

Chronic glucokinase activator treatment activates liver Carbohydrate response element binding protein and improves hepatocyte ATP homeostasis during substrate challenge.

Journal: Diabetes, obesity & metabolism

Published: April 07, 2020

11β-Hydroxysteroid dehydrogenase type 1 inhibition in idiopathic intracranial hypertension: a double-blind randomized controlled trial.

11β-Hydroxysteroid dehydrogenase type 1 inhibition in idiopathic intracranial hypertension: a double-blind randomized controlled trial.

Journal: Brain communications

Published: September 01, 2019

Therapy for Duchenne muscular dystrophy: renewed optimism from genetic approaches.

Therapy for Duchenne muscular dystrophy: renewed optimism from genetic approaches.

Journal: Nature reviews. Genetics

Published: April 24, 2013

Pharmacologically targeting the primary defect and downstream pathology in Duchenne muscular dystrophy.

Pharmacologically targeting the primary defect and downstream pathology in Duchenne muscular dystrophy.

Journal: Current gene therapy

Published: February 15, 2012

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Last Updated: 09/26/2026