Rebecca L. Brouillette

Sherbrooke, QC J1H5N4, Canada

Last Updated: 09/26/2026

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Found 18 publications

A neurotensin receptor type 1-derived pepducin acts as a biased allosteric modulator to regulate target receptor function.

A neurotensin receptor type 1-derived pepducin acts as a biased allosteric modulator to regulate target receptor function.

Journal: Acta pharmaceutica Sinica. B

Published: August 01, 2025

Opioid Analgesics: Rise and Fall of Ligand Biased Signaling and Future Perspectives in the Quest for the Holy Grail.

Opioid Analgesics: Rise and Fall of Ligand Biased Signaling and Future Perspectives in the Quest for the Holy Grail.

Journal: CNS drugs

Published: February 16, 2025

A lipidated peptide derived from the C-terminal tail of the vasopressin 2 receptor shows promise as a new β-arrestin inhibitor.

A lipidated peptide derived from the C-terminal tail of the vasopressin 2 receptor shows promise as a new β-arrestin inhibitor.

Journal: Pharmacological research

Published: August 23, 2024

Structure-based design of macrocyclic peptides to generate functional antibodies against G protein-coupled receptors.

Structure-based design of macrocyclic peptides to generate functional antibodies against G protein-coupled receptors.

Journal: Nature communications

Published: August 16, 2024

Design, Synthesis, and In Vitro Characterization of Proteolytically-Stable Opioid-Neurotensin Hybrid Peptidomimetics.

Design, Synthesis, and In Vitro Characterization of Proteolytically-Stable Opioid-Neurotensin Hybrid Peptidomimetics.

Journal: ACS pharmacology & translational science

Published: April 23, 2024

Discovery of a CCR2-targeting pepducin therapy for chronic pain.

Discovery of a CCR2-targeting pepducin therapy for chronic pain.

Journal: Pharmacological research

Published: January 26, 2024

Structural insight into apelin receptor-G protein stoichiometry.

Structural insight into apelin receptor-G protein stoichiometry.

Journal: Nature structural & molecular biology

Published: March 10, 2022

Structure-Based Virtual Screening of Ultra-Large Library Yields Potent Antagonists for a Lipid GPCR.

Structure-Based Virtual Screening of Ultra-Large Library Yields Potent Antagonists for a Lipid GPCR.

Journal: Biomolecules

Published: October 29, 2020

Data set describing the in vitro biological activity of JMV2009, a novel silylated neurotensin(8-13) analog.

Data set describing the in vitro biological activity of JMV2009, a novel silylated neurotensin(8-13) analog.

Journal: Data in brief

Published: May 13, 2020

Assessing Gαq/15-signaling with IP-One: Single Plate Transfection and Assay Protocol for Cell-Based High-Throughput Assay.

Assessing Gαq/15-signaling with IP-One: Single Plate Transfection and Assay Protocol for Cell-Based High-Throughput Assay.

Journal: Bio-protocol

Published: April 28, 2020

The P2Y6 receptor signals through Gαq /Ca2+ /PKCα and Gα13 /ROCK pathways to drive the formation of membrane protrusions and dictate cell migration.

The P2Y6 receptor signals through Gαq /Ca2+ /PKCα and Gα13 /ROCK pathways to drive the formation of membrane protrusions and dictate cell migration.

Journal: Journal of cellular physiology

Published: January 09, 2020

Pain relief devoid of opioid side effects following central action of a silylated neurotensin analog.

Pain relief devoid of opioid side effects following central action of a silylated neurotensin analog.

Journal: European journal of pharmacology

Published: December 20, 2019

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Last Updated: 09/26/2026