Ren Sheng

NHC Key Laboratory Of Microbial Drugs, State Key Laboratory Of Bioactive Substance And Function Of Natural Medicines, Chinese Academy Of Medical Sciences & Peking Union Medical College, Tiantan Xili 1#
Beijing, China

Last Updated: 09/26/2026

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Found 14 publications

Novel aromatic amide Pan-PPAR agonists for dual amelioration of hepatic steatosis and islet dysfunction by promoting cholesterol efflux in the KKAy diabetic mice.

Novel aromatic amide Pan-PPAR agonists for dual amelioration of hepatic steatosis and islet dysfunction by promoting cholesterol efflux in the KKAy diabetic mice.

Journal: European journal of medicinal chemistry

Published: April 23, 2026

Novel SIRT1 up-regulator F1462 attenuates endothelial cell senescence and vascular aging by promoting mitochondrial biogenesis via activating the SIRT1/PGC-1α/TFAM pathway.

Novel SIRT1 up-regulator F1462 attenuates endothelial cell senescence and vascular aging by promoting mitochondrial biogenesis via activating the SIRT1/PGC-1α/TFAM pathway.

Journal: European journal of pharmacology

Published: April 03, 2026

Research advances in ferroptosis in the regulation of metabolic dysfunction-associated steatotic liver disease

Research advances in ferroptosis in the regulation of metabolic dysfunction-associated steatotic liver disease

Journal: Sheng wu gong cheng xue bao = Chinese journal of biotechnology

Published: December 29, 2025

A Novel RANKL/RANK Inhibitor IMB-R38 Inhibits Osteoporosis Through Regulating Bone Metabolism.

A Novel RANKL/RANK Inhibitor IMB-R38 Inhibits Osteoporosis Through Regulating Bone Metabolism.

Journal: International journal of molecular sciences

Published: October 10, 2025

Discovery of potent and orally bioavailable benzothiazole-benzenesulfonamide derivatives as ABCA1 upregulators for the management of dyslipidemia.

Discovery of potent and orally bioavailable benzothiazole-benzenesulfonamide derivatives as ABCA1 upregulators for the management of dyslipidemia.

Journal: European journal of medicinal chemistry

Published: September 29, 2025

ASGR1 Deficiency Inhibits Atherosclerosis in Western Diet-Fed ApoE-/- Mice by Regulating Lipoprotein Metabolism and Promoting Cholesterol Efflux.

ASGR1 Deficiency Inhibits Atherosclerosis in Western Diet-Fed ApoE-/- Mice by Regulating Lipoprotein Metabolism and Promoting Cholesterol Efflux.

Journal: Arteriosclerosis, thrombosis, and vascular biology

Published: October 10, 2024

The novel small molecule E0924G dually regulates bone formation and bone resorption through activating the PPARδ signaling pathway to prevent bone loss in ovariectomized rats and senile mice.

The novel small molecule E0924G dually regulates bone formation and bone resorption through activating the PPARδ signaling pathway to prevent bone loss in ovariectomized rats and senile mice.

Journal: Bioorganic chemistry

Published: January 14, 2024

Antirheumatic drug leflunomide attenuates atherosclerosis by regulating lipid metabolism and endothelial dysfunction via DHODH/AMPK signaling pathway.

Antirheumatic drug leflunomide attenuates atherosclerosis by regulating lipid metabolism and endothelial dysfunction via DHODH/AMPK signaling pathway.

Journal: International journal of biological sciences

Published: December 21, 2023

A novel small-molecule PCSK9 inhibitor E28362 ameliorates hyperlipidemia and atherosclerosis.

A novel small-molecule PCSK9 inhibitor E28362 ameliorates hyperlipidemia and atherosclerosis.

Journal: Acta pharmacologica Sinica

Published: November 25, 2023

A pan-PPAR agonist E17241 ameliorates hyperglycemia and diabetic dyslipidemia in KKAy mice via up-regulating ABCA1 in islet, liver, and white adipose tissue.

A pan-PPAR agonist E17241 ameliorates hyperglycemia and diabetic dyslipidemia in KKAy mice via up-regulating ABCA1 in islet, liver, and white adipose tissue.

Journal: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Published: September 13, 2023

SIRT1 Activator E1231 Alleviates Nonalcoholic Fatty Liver Disease by Regulating Lipid Metabolism.

SIRT1 Activator E1231 Alleviates Nonalcoholic Fatty Liver Disease by Regulating Lipid Metabolism.

Journal: Current issues in molecular biology

Published: April 21, 2023

Trichostatin D as a Novel KLF2 Activator Attenuates TNFα-Induced Endothelial Inflammation.

Trichostatin D as a Novel KLF2 Activator Attenuates TNFα-Induced Endothelial Inflammation.

Journal: International journal of molecular sciences

Published: September 25, 2022

Showing 1-12 of 14

Last Updated: 09/26/2026